2,4,5,6-Tetrafluoropyrimidine

Base Information

• Chemical Name: 2,4,5,6-Tetrafluoropyrimidine
• CAS No.: 767-79-3
• Molecular Formula: C4F4N2
• Molecular Weight: 152.051
• Hs Code.: 2933599590
• Mol file: 767-79-3.mol

Synonyms:Pyrimidine,tetrafluoro;perfluoro-pyrimidine;tetrafluoro-pyrimidine;

Chemical Property of 2,4,5,6-Tetrafluoropyrimidine

Chemical Property:

• Vapor Pressure: 0.346mmHg at 25°C
• Boiling Point: 206.1°C at 760 mmHg
• Flash Point: 78.5°C
• PSA: 25.78000
• Density: 1.639g/cm³
• LogP: 1.03300

Purity/Quality:

98%min ^*data from raw suppliers

2,4,5,6-Tetrafluoropyrimidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,5,6-Tetrafluoropyrimidine

There total 8 articles about 2,4,5,6-Tetrafluoropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

helium + 2,4,6-trifluoropyrimidine (696-82-2) → 2,4,5,6-tetrafluoropyrimidine (767-79-3)

Guidance literature:

With fluorine; sodium fluoride; In trichlorofluoromethane;

Reference yield: 13.0%

tetrafluoropyridazine (7627-80-7) → 2,4,5,6-tetrafluoropyrimidine (767-79-3)

Guidance literature:

With perfluoro-3,4-dimethylhexane; at 300 ℃; for 16h; Product distribution; Mechanism; other perfluorinated compounds as promoters of the rearrangement; other temperature, time;

DOI:10.1039/P19810001071

Reference yield: 8.7%

2,4,6-trifluoropyrimidine (696-82-2) → 2,4,5,6-tetrafluoropyrimidine (767-79-3) + 2,4,6-trifluoro-5-chloropyrimidine (697-83-6)

Guidance literature:

With chlorine pentafluoride; In various solvent(s); at 0 ℃;

DOI:10.1016/S0022-1139(00)81475-X

upstream raw materials:

2,4,5,6-tetrachloropyrimidine

tetrafluoropyridazine

2,4,6-trifluoropyrimidine

perfluoro-4,5-di-s-butylpyridazine

Downstream raw materials:

2,5,6-trifluoro-4-(2,4,6-trimethylphenylazo)pyrimidine

2,5,6-trifluoro-N-phenylpyrimidin-4-amine

2,4,6-trifluoro-5-chloropyrimidine

Refernces

• 1、 Chambers, Richard D.,Gray, William K.,Korn, Stewart R.. "Reactions Involving Fluoride Ion. Part 40. Amines as Initiators of Fluoride Ion Catalysed Reactions". . p. 13167 - 13176. Retrieved 2007/10/03.
• 2、 Boudakian, Max M.,Hyde, Gene A.. "SUBSTITUTIVE AROMATIC FLUORINATION WITH CHLORINE PENTAFLUORIDE". . p. 435 - 446. Retrieved 2007/10/02.