2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (2E)-

Base Information

• Chemical Name: 2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (2E)-
• CAS No.: 142717-65-5
• Molecular Formula: C₁₂H₁₅NOS
• Molecular Weight: 221.323
• Mol file: 142717-65-5.mol

Synonyms:2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (E)-; Sinharine

Chemical Property of 2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (2E)-

There total 3 articles about 2-Propenamide,3-(methylthio)-N-(2-phenylethyl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(E)-N-(2-chloroethyl)cinnamamide (30687-03-7) + sodium thiomethoxide (5188-07-8) → (E)-N-<2-(methylthio)ethyl>cinnamamide (142717-65-5)

Guidance literature:

In ethanol; at 60 ℃;

Reference yield: 43.0%

(2-aminoethyl)methylsulfide (18542-42-2) + Cinnamoyl chloride (102-92-1,17082-09-6) → (E)-N-<2-(methylthio)ethyl>cinnamamide (142717-65-5)

Guidance literature:

With pyridine; In chloroform; for 1h;

DOI:10.1016/S0040-4020(01)80647-5

Reference yield:

Cinnamoyl chloride (102-92-1,17082-09-6) → (E)-N-<2-(methylthio)ethyl>cinnamamide (142717-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / triethylamine / CH₂Cl₂ / Ambient temperature

2: 60 percent / ethanol / 60 °C

With triethylamine; In ethanol; dichloromethane;

upstream raw materials:

(E)-N-(2-chloroethyl)cinnamamide

sodium thiomethoxide

(2-aminoethyl)methylsulfide

Cinnamoyl chloride