Zacopride hydrochloride

Base Information

• Chemical Name: Zacopride hydrochloride
• CAS No.: 101303-98-4
• Molecular Formula: C15H20 Cl N3 O2 . Cl H
• Molecular Weight: 425.869
• UNII: BJ3775635U
• DSSTox Substance ID: DTXSID4045686
• Wikidata: Q27274695
• NCI Thesaurus Code: C152943
• ChEMBL ID: CHEMBL2104901
• Mol file: 101303-98-4.mol

Synonyms:4-amino-5-iodo-2-methoxy-N-(1-azabicyclo(2.2.2)oct-3-yl)benzamide;4-amino-N-(1-azabicyclo(2,2,2)oct-3-yl)-5-chloro-2-methoxybenzamide-2-butenedioate;iodozacopride;zacopride;zacopride hydrochloride

Chemical Property of Zacopride hydrochloride

Chemical Property:

• Melting Point: 158-160 °C
• PSA: 71.08000
• LogP: 3.65070
• Storage Temp.: 2-8°C
• Solubility.: H2O: ≥10mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 345.1010823
• Heavy Atom Count: 22
• Complexity: 387

Purity/Quality:

98%min ^*data from raw suppliers

ZacoprideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N.Cl
• Uses: Zacopride Hydrochloride, is a highly potent SR-3 antagonist and SR-4 agonist. 5-HT3 receptor antagonist. Activates IK1 channel.

Technology Process of Zacopride hydrochloride

There total 1 articles about Zacopride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Zacopride fumarate (101303-98-4)

Guidance literature:

Reference yield:

phosphorous pentasulfide + Zacopride fumarate (101303-98-4) → 4-Amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxythiobenzamide, fumarate

Guidance literature:

With potassium sulphide; In (2E)-but-2-enedioic acid;

Reference yield:

phosphorous pentasulphide + potassium sulphide (1312-73-8) + Zacopride fumarate (101303-98-4) → 4-Amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxythiobenzamide, fumarate

Guidance literature:

In (2E)-but-2-enedioic acid;

Refernces

• 1、 -. "2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs". . . Retrieved 2008/06/13.
• 2、 -. "Anxiolytic-N-(1-Azabicyclo[2.2.2]Oct-3-yl) Benzamides and Thobenzamides". . . Retrieved 2008/06/13.