4-(4-methoxyphenoxy)butanoic acid

Base Information

• Chemical Name: 4-(4-methoxyphenoxy)butanoic acid
• CAS No.: 55579-99-2
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• Mol file: 55579-99-2.mol

Synonyms:4-(p-methoxyphenoxy)butyric acid;4-(4-Methoxyphenoxy)butyric Acid;p-methoxy phenoxybutyric acid;4-(4-Methoxy-phenoxy)-buttersaeure;4-(4-Methoxyphenyl)oxybutanic acid;

Chemical Property of 4-(4-methoxyphenoxy)butanoic acid

Chemical Property:

• Vapor Pressure: 6.29E-07mmHg at 25°C
• Boiling Point: 394.4°Cat760mmHg
• Flash Point: 155°C
• PSA: 55.76000
• Density: 1.157g/cm³
• LogP: 1.93880

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Methoxyphenoxy)butyricAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-(4-Methoxyphenoxy)butyric Acid is a reactant used in the preparation of anti-implantation agents and hallucinogenic phenethylamines analogs.

Technology Process of 4-(4-methoxyphenoxy)butanoic acid

There total 6 articles about 4-(4-methoxyphenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-one (201486-52-4) → 4-(4-Methoxyphenoxy)butyric Acid (55579-99-2)

Guidance literature:

With sodium hydroxide; In methanol; for 3.3h; Product distribution; other reag.; other solvent;

DOI:10.1016/S0040-4039(97)10491-9

Reference yield: 93.0%

4-butanolide (96-48-0) + 4-methoxy-phenol (150-76-5) → 4-(4-Methoxyphenoxy)butyric Acid (55579-99-2)

Guidance literature:

With potassium hydroxide; In water; at 150 - 195 ℃; for 5h;

DOI:10.1021/jo990011e

Reference yield:

NaOC2 H5 + 4-methoxy-phenol (150-76-5) → 4-(4-Methoxyphenoxy)butyric Acid (55579-99-2)

Guidance literature:

In ethanol;

upstream raw materials:

4-(4-methoxyphenoxy)butyric acid ethyl ester

4-butanolide

4-methoxy-phenol

1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-one

Downstream raw materials:

7-methoxy-3,4-dihydro-1-benzoxepin-5(2H)-one

(4S)-4-benzyl-3-[[4'-(4-methoxyphenyl)oxy]butyloyl]-2-oxazolidinone

diethyl 6-ethoxy-3,6-dihydro-4-[3-(p-methoxyphenoxy)propyl]-2H-thiopyran-2,2-dicarboxylate

6-ethoxy-3,6-dihydro-4-[3-(p-methoxyphenoxy)propyl]-2H-thiopyran-2,2-dimethanol

Refernces

• 1、 -. "Substituted tetralins, chromans and related compounds in the treatment of asthma". . . Retrieved 2008/06/13.
• 2、 Arai, Eri,Tokuyama, Hidetoshi,Linsell, Martin S.,Fukuyama, Tohru. "2-(2-aminophenyl)-acetaldehyde dimethyl acetal: A novel reagent for the protection of carboxylic acids". . p. 71 - 74. Retrieved 2007/10/03.