o-ACETOTOLUIDIDE, 2-DIETHYLAMINO-

Base Information

• Chemical Name: o-ACETOTOLUIDIDE, 2-DIETHYLAMINO-
• CAS No.: 3213-14-7
• Molecular Formula: C13H20 N2 O
• Molecular Weight: 220.315
• DSSTox Substance ID: DTXSID30185910
• Nikkaji Number: J83.929I
• Wikidata: Q83057067
• ChEMBL ID: CHEMBL271307
• Mol file: 3213-14-7.mol

Synonyms:2-Diethylamino-o-acetotoluidide;o-ACETOTOLUIDIDE, 2-DIETHYLAMINO-;BRN 2371471;Acetamide, 2-(diethylamino)-N-(2-methylphenyl)-;3213-14-7;4-12-00-01782 (Beilstein Handbook Reference);CHEMBL271307;SCHEMBL14605471;DTXSID30185910;2-Diethylamino-N-o-tolylacetamide;diethylaminoacetic acid o-toluidide;AKOS002844456

Chemical Property of o-ACETOTOLUIDIDE, 2-DIETHYLAMINO-

Chemical Property:

• Vapor Pressure: 3.78E-05mmHg at 25°C
• Boiling Point: 352.7°C at 760 mmHg
• Flash Point: 167.1°C
• Density: 1.038g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 220.157563266
• Heavy Atom Count: 16
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC(=O)NC1=CC=CC=C1C

Technology Process of o-ACETOTOLUIDIDE, 2-DIETHYLAMINO-

There total 3 articles about o-ACETOTOLUIDIDE, 2-DIETHYLAMINO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

diethylamine (109-89-7) + 2-chloro-N-(2-methylphenyl)acetamide (37394-93-7) → 2-(diethylamino)-N-(2-methyl-phenyl)acetamide (3213-14-7)

Guidance literature:

In benzene; for 5h; Reflux;

DOI:10.1134/S1070428019100117

Reference yield:

o-toluidine (95-53-4) → 2-(diethylamino)-N-(2-methyl-phenyl)acetamide (3213-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 0 °C

2: benzene / 5 h / Reflux

In benzene;

DOI:10.1134/S1070428019100117

Reference yield:

→ 2-(diethylamino)-N-(2-methyl-phenyl)acetamide (3213-14-7)

Guidance literature:

N-Chloracetyl-o-toluidin in Methanol, Diethylamin, Erwaerm.;

DOI:10.1248/cpb.15.8

upstream raw materials:

diethylamine

2-chloro-N-(2-methylphenyl)acetamide

o-toluidine

Refernces

• 1、 Costa, Jorge C.S.,Neves, Josiane S.,de Souza, Marcus V.N.,Siqueira, Rodrigo A.,Romeiro, Nelilma C.,Boechat, Nubia,Silva, Patricia M.R.e,Martins, Marco A.. "Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action". . p. 1162 - 1166. Retrieved 2008/09/20.