Technology Process of 2-Butenoic acid, 2-methyl-4-(phenylmethoxy)-, methyl ester, (E)-
There total 6 articles about 2-Butenoic acid, 2-methyl-4-(phenylmethoxy)-, methyl ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol5020043
- Guidance literature:
-
Multi-step reaction with 2 steps
1: oxalyl chloride, dimethylsulfoxide / CH2Cl2 / 0.5 h / -78 °C
2: 1.) 18-crown-6, <(CH3)3Si>2NK (KHMDS) / 1.) THF, toluene, -78 deg C, 5 min, 2.) -78 deg C, 45 min
With
oxalyl dichloride; 18-crown-6 ether; potassium hexamethylsilazane; dimethyl sulfoxide;
In
dichloromethane;
DOI:10.1021/jo00253a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF 2.) reflux, 16 h
2: oxalyl chloride, dimethylsulfoxide / CH2Cl2 / 0.5 h / -78 °C
3: 1.) 18-crown-6, <(CH3)3Si>2NK (KHMDS) / 1.) THF, toluene, -78 deg C, 5 min, 2.) -78 deg C, 45 min
With
oxalyl dichloride; 18-crown-6 ether; potassium hexamethylsilazane; sodium hydride; dimethyl sulfoxide;
In
dichloromethane;
DOI:10.1021/jo00253a020
