4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]benzamide

Base Information

• Chemical Name: 4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]benzamide
• CAS No.: 23205-22-3
• Molecular Formula: C20H26 Cl N3 O2
• Molecular Weight: 375.8923

Synonyms:Benzamide,4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]- (8CI)

Chemical Property of 4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]benzamide

Chemical Property:

• Vapor Pressure: 1.19E-10mmHg at 25°C
• Boiling Point: 513.4°C at 760 mmHg
• Flash Point: 264.3°C
• Density: 1.18g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]benzamide

There total 3 articles about 4-amino-2-(benzyloxy)-5-chloro-N-[2-(diethylamino)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide (38339-95-6) + benzyl bromide (100-39-0) → 4-Amino-2-benzyloxy-5-chloro-N-(2-diethylamino-ethyl)-benzamide (23205-22-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;

DOI:10.1021/jm00403a011

Reference yield:

metoclopramide (364-62-5) → 4-Amino-2-benzyloxy-5-chloro-N-(2-diethylamino-ethyl)-benzamide (23205-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / sodium hydride, ethanethiol / dimethylformamide / 1.5 h / 100 - 105 °C

2: 51 percent / sodium hydride / dimethylformamide / 16 h / Ambient temperature

With sodium hydride; ethanethiol; In N,N-dimethyl-formamide;

DOI:10.1021/jm00403a011

Reference yield:

→ 4-Amino-2-benzyloxy-5-chloro-N-(2-diethylamino-ethyl)-benzamide (23205-22-3)

Guidance literature:

Benzoat II, Diamin III;

upstream raw materials:

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide

benzyl bromide

metoclopramide

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