Benzoxazole, 2-[(4-chlorophenyl)methyl]-

Base Information

• Chemical Name: Benzoxazole, 2-[(4-chlorophenyl)methyl]-
• CAS No.: 101554-06-7
• Molecular Formula: C14H10ClNO
• Molecular Weight: 243.692
• Mol file: 101554-06-7.mol

Synonyms:2-(4-Chloro-benzyl)-benzooxazole;2-(p-chlorobenzyl)benzoxazole;

Chemical Property of Benzoxazole, 2-[(4-chlorophenyl)methyl]-

Chemical Property:

• PSA: 26.03000
• LogP: 4.07200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoxazole, 2-[(4-chlorophenyl)methyl]-

There total 6 articles about Benzoxazole, 2-[(4-chlorophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzoxazole (273-53-0,29791-96-6) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-(4-chlorobenzyl)benzo[d]oxazole (101554-06-7)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 120 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201200025

Reference yield: 80.0%

2-phenoxy-1,3-benzoxazole (50400-41-4) + 2-(4-chlorophenyl)-1-phenylethanone (6332-83-8) → benzoic acid phenyl ester (93-99-2) + 2-(4-chlorobenzyl)benzo[d]oxazole (101554-06-7)

Guidance literature:

With hydridotetakis(triphenylphosphine)rhodium(I); o-phenylenebis(diphenylphosphine); In chlorobenzene; for 6h; Inert atmosphere; Reflux;

DOI:10.1039/c4cc00816b

Reference yield: 71.0%

4-vinylbenzyl chloride (1073-67-2,24991-47-7) + 2-amino-phenol (95-55-6) → 2-(4-chlorobenzyl)benzo[d]oxazole (101554-06-7)

Guidance literature:

With N-methylcyclohexylamine; sulfur; at 110 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.joc.1c01357

upstream raw materials:

1-chloro-4-(2,2-dibromovinyl)benzene

2-amino-phenol

benzoxazole

1-Chloro-4-(chloromethyl)benzene

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