4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-

Base Information

Chemical Name:4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-
CAS No.:101979-60-6
Molecular Formula:C14H19NO3
Molecular Weight:249.31
Hs Code.:
DSSTox Substance ID:DTXSID201196385
Mol file:101979-60-6.mol

Synonyms:4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-;DTXSID201196385;101979-60-6

Suppliers and Price of 4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:249.13649347
Heavy Atom Count:18
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=CC(CC(=O)NOCC1=CC=CC=C1)O)C
Isomeric SMILES:CC(=C[C@@H](CC(=O)NOCC1=CC=CC=C1)O)C

Technology Process of 4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)-

There total 5 articles about 4-Hexenamide, 3-hydroxy-5-methyl-N-(phenylmethoxy)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

: 101979-59-3
(R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-hex-4-enoic acid benzyloxy-amide

: 101979-60-6
(R)-3-Hydroxy-5-methyl-hex-4-enoic acid benzyloxy-amide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo00362a047

Reference yield:

: 107-86-8
3,3-dimethyl acrylaldehyde

: 101979-60-6
(R)-3-Hydroxy-5-methyl-hex-4-enoic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-ethylpiperidine, tin(II) triflate / 1.) CH₂Cl₂, -50 to -40 deg C, 4 h, 2.) CH₂Cl₂, -78 deg C, 30 min

2: 91.4 percent / imidazole / CH₂Cl₂ / 0 °C

3: 65 percent / Et₃N / CH₂Cl₂

4: 71.7 percent / Bu₄NF / tetrahydrofuran

With 1-ethyl-piperidine; 1H-imidazole; tin(II) trifluoromethanesulfonate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00362a047

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 101979-60-6
(R)-3-Hydroxy-5-methyl-hex-4-enoic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Et₃N / CH₂Cl₂

2: 71.7 percent / Bu₄NF / tetrahydrofuran

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00362a047