O-Benzylhydroxylamine hydrochloride

Base Information

• Chemical Name: O-Benzylhydroxylamine hydrochloride
• CAS No.: 2687-43-6
• Molecular Formula: C7H9NO^.HCl
• Molecular Weight: 159.615
• Hs Code.: 29280000
• European Community (EC) Number: 220-249-0
• NSC Number: 4248
• DSSTox Substance ID: DTXSID40181382
• Mol file: 2687-43-6.mol

Synonyms:benzyloxyamine;benzyloxyamine hydrochloride;O-benzylhydroxylamine

Chemical Property of O-Benzylhydroxylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00923mmHg at 25°C
• Melting Point: 238 °C (subl.)(lit.)
• Boiling Point: 237.5 °C at 760 mmHg
• Flash Point: 113.1 °C
• PSA: 35.25000
• LogP: 2.57920
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: Soluble in DMSO and methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 159.0450916
• Heavy Atom Count: 10
• Complexity: 69.3

Purity/Quality:

99% ^*data from raw suppliers

O-Benzylhydroxylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-24/25-8-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydroxylamines
• Canonical SMILES: C1=CC=C(C=C1)CON.Cl
• Uses: O-Benzylhydroxylamine hydrochloride is a reagent used for the synthesis of hydroxylamines and hydroxyamates. For use in the formation of nitrones from carbonyl compounds and their use in cycloaddition reactions. Used as a reagent used in the synthesis of hydroxylamines and hydroxyamates. Effective reagent used to prepare α-hydroxybenzylamines from α-hydroxyketones.

Technology Process of O-Benzylhydroxylamine hydrochloride

There total 21 articles about O-Benzylhydroxylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.72%

acetone O-benzyloxime (3376-36-1) → O-benzylhydoxylamine hydrochloride (2687-43-6)

Guidance literature:

With hydrogenchloride; In methanol; water; at 36 ℃; for 3.5h;

Reference yield: 98.3%

pentan-3-one O-benzyloxime (18630-84-7) → O-benzylhydoxylamine hydrochloride (2687-43-6)

Guidance literature:

With hydrogenchloride; In methanol; water; at 38 ℃; for 3.33333h;

Reference yield: 97.4%

ethyl methyl ketone oxime (96-29-7) + benzyl bromide (100-39-0) → O-benzylhydoxylamine hydrochloride (2687-43-6)

Guidance literature:

ethyl methyl ketone oxime; benzyl bromide; With sodium ethanolate; In ethanol; at 40 ℃; for 1h;

With dioctyltin dilaurate; In ethanol; at 40 ℃; for 6h;

With hydrogenchloride; In water; Temperature; Reagent/catalyst; Solvent;

upstream raw materials:

N-benzyloxy benzamide

3-hydroxy-4-thiochromanone dimethylketal

N-(benzyloxy)phthalimide

1-(benzyloxy)pyrrolidine-2,5-dione

Downstream raw materials:

heptanal-(O-benzyl oxime )

formaldehyde O-benzyloxime

N,O-dibenzylhydroxylamine

N,N,O-tribenzylhydroxylamine

Refernces

• 1、 Saha, Debarshi,Taily, Irshad Maajid,Naik, Sumitra,Banerjee, Prabal. "Electrochemical access to benzimidazolone and quinazolinone derivatives: Via in situ generation of isocyanates". supporting information. p. 631 - 634. Retrieved 2021/01/29.
• 2、 -. "Preparation method of benzyloxyamine hydrochloride". Paragraph 0035-0037; 0040. . Retrieved 2021/04/14.