2-Cyclopropene-1,1-dicarboxylic acid, dimethyl ester

Base Information

• Chemical Name: 2-Cyclopropene-1,1-dicarboxylic acid, dimethyl ester
• CAS No.: 102127-47-9
• Molecular Formula: C7H8O4
• Molecular Weight: 156.138
• Mol file: 102127-47-9.mol

Synonyms:

Chemical Property of 2-Cyclopropene-1,1-dicarboxylic acid, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyclopropene-1,1-dicarboxylic acid, dimethyl ester

There total 1 articles about 2-Cyclopropene-1,1-dicarboxylic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyl diazomalonate (6773-29-1) + trimethylsilylacetylene (1066-54-2) → dimethyl ester of 1H,2H-cyclopropene-3,3-dicarboxylic acid (102127-47-9) + 2-methoxy-4-trimethylsilylfuran-3-carboxylic acid methyl ester

Guidance literature:

dimethyl diazomalonate; trimethylsilylacetylene; dirhodium tetraacetate; at 60 ℃; for 22h;

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1055/s-2003-44368

Reference yield: 93.0%

N-(pivaloyloxy)-[1,1'-biphenyl]-4-carboxamide (1352801-42-3) + dimethyl ester of 1H,2H-cyclopropene-3,3-dicarboxylic acid (102127-47-9) → dimethyl 2-(1-oxo-6-phenyl-1,2-dihydroisoquinolin-4-yl)malonate (1474060-40-6)

Guidance literature:

N-(pivaloyloxy)-[1,1'-biphenyl]-4-carboxamide; With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; for 0.00833333h; Inert atmosphere;

dimethyl ester of 1H,2H-cyclopropene-3,3-dicarboxylic acid; In methanol; at 23 ℃; for 8h; Inert atmosphere;

DOI:10.1055/s-0033-1339510

Reference yield: 92.0%

trans-cinnamyl iodide (82859-39-0) + dimethyl ester of 1H,2H-cyclopropene-3,3-dicarboxylic acid (102127-47-9) → (E,E)-2-(2'-iodovinyl)-2-(3''-phenyl-2''-propenyl)malonic acid dimethyl ester

Guidance literature:

With sodium carbonate; sodium iodide; In acetone; Heating;

DOI:10.1021/ja038131y

upstream raw materials:

dimethyl diazomalonate

trimethylsilylacetylene

Downstream raw materials:

2-[3-(4-methoxyphenyl)isoxazol-4-yl]malonic acid dimethyl ester

dimethyl 2-(5-phenylpyrazolo[5,1-a]isoquinolin-1-yl)malonate

dimethyl 2-(5-(4-fluorophenyl)pyrazolo[5,1-a]isoquinolin-1-yl)malonate

dimethyl 2-(5-(4-methoxyphenyl)pyrazolo[5,1-a]isoquinolin-1-yl)malonate