1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)-

Base Information

• Chemical Name: 1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)-
• CAS No.: 102152-10-3
• Molecular Formula: C14H12N2OS
• Molecular Weight: 256.328
• DSSTox Substance ID: DTXSID20475998
• Nikkaji Number: J2.150.288J
• Wikidata: Q82306863
• Mol file: 102152-10-3.mol

Synonyms:102152-10-3;4-(4-METHOXYPHENYL)-2-(THIOPHEN-2-YL)-1H-IMIDAZOLE;1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)-;5-(4-Methoxyphenyl)-2-(2-thienyl)-1H-imidazole;DTXSID20475998

Chemical Property of 1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)-

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 256.06703418
• Heavy Atom Count: 18
• Complexity: 269

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CN=C(N2)C3=CC=CS3

Technology Process of 1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)-

There total 1 articles about 1H-Imidazole, 4-(4-methoxyphenyl)-2-(2-thienyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-thiophenecarboxamidine (54610-75-2) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 5-(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole (102152-10-3)

Guidance literature:

With potassium hydrogencarbonate; In tetrahydrofuran; water; for 2.5h; Reflux;

DOI:10.1021/op025552b

Reference yield: 86.0%

5-(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole (102152-10-3) → 4-(p-hydroxyphenyl)-2-(2-thienyl)imidazole (102152-11-4)

Guidance literature:

With hydrogen bromide; In acetic acid; for 2.5h; Heating;

DOI:10.1021/jm00156a028

Reference yield:

5-(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole (102152-10-3) → (S)-3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-phenyl-5-[4-(2-thiophen-2-yl-3H-imidazol-4-yl)-phenoxymethyl]-oxazolidine

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / HBr / acetic acid / 2.5 h / Heating

2: 1.) NaH / 1.) DMF, 70 deg C, 15 min, 2.) DMF, 120 deg C, 18 h

With hydrogen bromide; sodium hydride; In acetic acid;

DOI:10.1021/jm00156a028

upstream raw materials:

2-thiophenecarboxamidine

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

4-(p-hydroxyphenyl)-2-(2-thienyl)imidazole