(z)-4-(4-Hydroxybenzylidene)-2-phenyloxazol-5(4h)-one

Base Information

• Chemical Name: (z)-4-(4-Hydroxybenzylidene)-2-phenyloxazol-5(4h)-one
• CAS No.: 1226-71-7
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.268
• NSC Number: 143232

Synonyms:(z)-4-(4-hydroxybenzylidene)-2-phenyloxazol-5(4h)-one;NSC143232;NPD5902;1226-71-7;STL553705;AKOS027466465;NSC-143232;(4Z)-4-(4-Hydroxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one;(4Z)-4-(4-Hydroxybenzylidene)-2-phenyl-1,3-oxazol-5(4H)-one #;4,5-Dihydroxyoxazole-5-one, 4-[4-hydroxybenzylidene]-2-phenyl-;82301-52-8

Chemical Property of (z)-4-(4-Hydroxybenzylidene)-2-phenyloxazol-5(4h)-one

Chemical Property:

• Vapor Pressure: 4.04E-08mmHg at 25°C
• Boiling Point: 433.5°Cat760mmHg
• Flash Point: 215.9°C
• Density: 1.26g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 265.07389321
• Heavy Atom Count: 20
• Complexity: 427

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CC3=CC=C(C=C3)O)C(=O)O2
• Isomeric SMILES: C1=CC=C(C=C1)C2=N/C(=C\C3=CC=C(C=C3)O)/C(=O)O2

Technology Process of (z)-4-(4-Hydroxybenzylidene)-2-phenyloxazol-5(4h)-one

There total 5 articles about (z)-4-(4-Hydroxybenzylidene)-2-phenyloxazol-5(4h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(4-hydroxybenzylidene)-2-phenyloxazol-5(4H)-one (1226-71-7,57427-89-1,82301-52-8)

Guidance literature:

With acetic anhydride; 5-sulfosalicylic Acid; In water; at 20 ℃; for 0.666667h; Green chemistry;

DOI:10.3987/COM-17-13711

Reference yield: 73.0%

2-phenylazlactone (1199-01-5,53766-22-6) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(4-hydroxybenzylidene)-2-phenyloxazol-5(4H)-one (1226-71-7,57427-89-1,82301-52-8)

Guidance literature:

With piperidine; In 1,4-dioxane; Heating;

Reference yield:

2-benzoylamino-3-(4-hydroxy-phenyl)-acrylic acid (32089-82-0) → 4-(4-hydroxybenzylidene)-2-phenyloxazol-5(4H)-one (1226-71-7,57427-89-1,82301-52-8)

Guidance literature:

With thionyl chloride; at 85 ℃;

DOI:10.1002/jps.2600530918

upstream raw materials:

2-benzoylamino-3-(4-hydroxy-phenyl)-acrylic acid

Hippuric Acid

4-hydroxy-benzaldehyde

2-phenylazlactone

Downstream raw materials:

N-{4-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-isonicotinamide

1,4-Bis(5'-(4-hydroxybenzylidene)-2'-phenyl-4'-imidazolinone-3'-ylamino)phthalazine

C₂₂H₁₆N₄O₃

C₂₈H₂₁N₃O₃

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