Thieno[2,3-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[(phenylamino)thioxomethyl]amino]-6-(phenylmeth yl)-, ethyl ester

Base Information

• Chemical Name: Thieno[2,3-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[(phenylamino)thioxomethyl]amino]-6-(phenylmeth yl)-, ethyl ester
• CAS No.: 102609-56-3
• Molecular Formula: C24H25N3O2S2
• Molecular Weight: 451.60400
• Mol file: 102609-56-3.mol

Synonyms:6-benzyl-2-(3-phenylthioureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;6-Benzyl-2-(3-phenyl-thioureido)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;

Chemical Property of Thieno[2,3-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[(phenylamino)thioxomethyl]amino]-6-(phenylmeth yl)-, ethyl ester

Chemical Property:

• PSA: 113.93000
• LogP: 5.37590

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[2,3-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[(phenylamino)thioxomethyl]amino]-6-(phenylmeth yl)-, ethyl ester

There total 2 articles about Thieno[2,3-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-2-[[(phenylamino)thioxomethyl]amino]-6-(phenylmeth yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tinoridine (24237-54-5) + phenyl isothiocyanate (103-72-0) → 2-(3-Phenyl-thioureido)-6-benzyl-4,5,6,7-tetrahydro-thieno<2,3-c>pyridin-3-carbonsaeureethylester (102609-56-3)

Guidance literature:

Microwave irradiation; Neat (no solvent);

DOI:10.3390/molecules15063932

Reference yield: 75.0%

phenyl isothiocyanate (103-72-0) + 6-Benzyl-2-isothiocyanato-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester → 2-(3-Phenyl-thioureido)-6-benzyl-4,5,6,7-tetrahydro-thieno<2,3-c>pyridin-3-carbonsaeureethylester (102609-56-3)

Guidance literature:

In ethanol; for 18h; Heating;

DOI:10.1055/s-1987-33428

Reference yield: 95.0%

2-(3-Phenyl-thioureido)-6-benzyl-4,5,6,7-tetrahydro-thieno<2,3-c>pyridin-3-carbonsaeureethylester (102609-56-3) + methyl iodide (74-88-4) → 7-Benzyl-2-methylsulfanyl-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one (105543-95-1)

Guidance literature:

With sodium hydroxide; In ethanol; 10 min, heating; 50 min, RT;

upstream raw materials:

tinoridine

phenyl isothiocyanate

Downstream raw materials:

2-(2-Amino-ethylsulfanyl)-7-benzyl-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one

(7-Benzyl-4-oxo-3-phenyl-3,4,5,6,7,8-hexahydro-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-ylsulfanyl)-acetic acid ethyl ester

7-Benzyl-2-phenylamino-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one

7-Benzyl-2-(2-hydroxy-ethylsulfanyl)-3-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-one

Refernces

• 1、 Al-Taisan, Khulud M.,Al-Hazimi, Hassan M. A.,Al-Shihry, Shar S.. "Synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines". experimental part. p. 3932 - 3957. Retrieved 2010/09/18.
• 2、 Leistner, Siegfried,Guetschow, Michael,Wagner, Guenther. "The Facile Synthesis of 2-Aminothienothiazin-4-ones, in Some Cases 5,6-Anelated". . p. 466 - 470. Retrieved 2007/10/02.