2-Methyl-3,4-diphenylquinoline

Base Information

• Chemical Name: 2-Methyl-3,4-diphenylquinoline
• CAS No.: 10266-18-9
• Molecular Formula: C22H17N
• Molecular Weight: 295.384
• DSSTox Substance ID: DTXSID60497275
• Nikkaji Number: J502.126J
• Wikidata: Q82346701
• Mol file: 10266-18-9.mol

Synonyms:2-Methyl-3,4-diphenylquinoline;10266-18-9;SCHEMBL5434073;DTXSID60497275

Chemical Property of 2-Methyl-3,4-diphenylquinoline

Chemical Property:

• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 295.136099547
• Heavy Atom Count: 23
• Complexity: 366

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=C1C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2-Methyl-3,4-diphenylquinoline

There total 9 articles about 2-Methyl-3,4-diphenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Acetanilid (103-84-4) + diphenyl acetylene (501-65-5) → 2-methyl-3,4-diphenylquinoline (10266-18-9)

Guidance literature:

Acetanilid; With 2,6-dichloropyridine; trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; at -78 - 0 ℃; for 0.416667h; Inert atmosphere;

diphenyl acetylene; In dichloromethane; 1,2-dichloro-ethane; at 90 ℃; for 14h; Concentration; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201703832

Reference yield: 93.0%

(E)-1-phenylethanone oxime (10341-75-0) + diphenyl acetylene (501-65-5) → 2-methyl-3,4-diphenylquinoline (10266-18-9)

Guidance literature:

With trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; at 0 - 80 ℃; for 12h; Reagent/catalyst; Temperature; Time;

DOI:10.1002/adsc.201801724

Reference yield: 92.0%

1-phenyl-acetone (103-79-7,136675-26-8) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 2-methyl-3,4-diphenylquinoline (10266-18-9)

Guidance literature:

KAl(SO₄)2*12H₂O/SiO₂; at 30 ℃; for 2.45h;

DOI:10.3987/COM-07-11273

upstream raw materials:

1-phenyl-acetone

(2-aminophenyl)(phenyl)methanone

Acetanilid

diphenyl acetylene

Downstream raw materials:

2-(3,4-diphenylquinolyliden-2-yl)-1-phenylethanone

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