2,2-Dimethyl-4-methylidenepentanedioic acid

Base Information

• Chemical Name: 2,2-Dimethyl-4-methylidenepentanedioic acid
• CAS No.: 10297-25-3
• Molecular Formula: C8H12O4
• Molecular Weight: 172.181
• DSSTox Substance ID: DTXSID00603873
• Nikkaji Number: J2.064.908I
• Wikidata: Q82501461
• Mol file: 10297-25-3.mol

Synonyms:10297-25-3;2,2-Dimethyl-4-methylidenepentanedioic acid;SCHEMBL2524423;DTXSID00603873;2-methylene-4,4-dimethylglutaric acid

Chemical Property of 2,2-Dimethyl-4-methylidenepentanedioic acid

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 172.07355886
• Heavy Atom Count: 12
• Complexity: 227

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(CC(=C)C(=O)O)C(=O)O

Technology Process of 2,2-Dimethyl-4-methylidenepentanedioic acid

There total 2 articles about 2,2-Dimethyl-4-methylidenepentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

crotonic acid sodium salt (17342-77-7) + sodium methacrylate (5536-61-8) → 2,2-dimethyl-4-methylenepentanedioic acid (10297-25-3) + hex-1-ene-2,5-dicarboxylic acid (5363-70-2) + hex-1-ene-3,4-dicarboxylic acid (87817-18-3) + hex-1-ene-2,4-dicarboxylic acid

Guidance literature:

In solid; at 250 ℃; for 3h; Product distribution; Mechanism; other metal salts; var. temp.;

DOI:10.1039/c39920000105

Reference yield:

sodium methacrylate (5536-61-8) + but-3-enoic acid sodium salt (19295-87-5) → 2,2-dimethyl-4-methylenepentanedioic acid (10297-25-3) + hex-1-ene-2,5-dicarboxylic acid (5363-70-2) + 1-hexene-1,6-dicarboxylic acid + (E)-6-Methyl-hept-2-enedioic acid

Guidance literature:

at 200 ℃; for 2h; Product distribution; Mechanism; other alkali and alkaline earth salts; var. temperatures;

DOI:10.1039/P29960000889

Reference yield: 88.9%

2,2-dimethyl-4-methylenepentanedioic acid (10297-25-3) + 2-(4-dimethylaminophenyl)ethyl alcohol (50438-75-0) → C28H38N2O4

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In ethyl acetate; at 0 - 20 ℃; Inert atmosphere;

upstream raw materials:

crotonic acid sodium salt

sodium methacrylate

but-3-enoic acid sodium salt

Downstream raw materials:

C₂₆H₃₂O₈

AFM-4