2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde
• CAS No.: 103844-29-7
• Molecular Formula: C15H11ClN2O
• Molecular Weight: 270.718
• DSSTox Substance ID: DTXSID001165590
• Mol file: 103844-29-7.mol

Synonyms:SCHEMBL1431015;MQOLPCNMJQQNIT-UHFFFAOYSA-N;DTXSID001165590;2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde;2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carboxaldehyde;103844-29-7

Chemical Property of 2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 270.0559907
• Heavy Atom Count: 19
• Complexity: 330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN2C(=NC(=C2C=O)C3=CC=C(C=C3)Cl)C=C1

Technology Process of 2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde

There total 2 articles about 2-(4-Chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + 4-chlorocinnamaldehyde (1075-77-0) → 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde (103844-29-7)

Guidance literature:

With copper(I) bromide; In ethanol; at 60 ℃; for 8h;

DOI:10.1039/c5ob00776c

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine (103844-28-6) → 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde (103844-29-7)

Guidance literature:

N,N-dimethyl-formamide; 2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine; With trichlorophosphate; at 20 - 100 ℃; for 0.5h; Inert atmosphere;

With sodium carbonate;

Reference yield: 81.0%

2-(1H-pyrrol-1-yl)aniline (6025-60-1) + 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde (103844-29-7) → 2-(4-chlorophenyl)-6-methyl-3-{4H,5H-pyrrolo[1,2-a]quinoxalin-4-yl}imidazo[1,2-a]pyridine

Guidance literature:

In water; at 20 ℃; for 3h; Green chemistry;

DOI:10.1002/ardp.202000192

upstream raw materials:

N,N-dimethyl-formamide

2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine

(5-methyl-pyridin-2-yl)amine

4-chlorocinnamaldehyde

Downstream raw materials:

1-[2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl]ethanol