2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine
• CAS No.: 103844-28-6
• Molecular Formula: C14H11ClN2
• Molecular Weight: 242.708
• Mol file: 103844-28-6.mol

Synonyms:6-methyl-2-(4-chlorophenyl)imidazo[1,2-a]pyridine;2-(4-Chloro-phenyl)-6-methyl-imidazo[1,2-a]pyridine;

Chemical Property of 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 145 °C
• PSA: 17.30000
• LogP: 3.96310

Purity/Quality:

2-(4-CHLOROPHENYL)-6-METHYL-IMIDAZO[1,2-A]PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine

There total 6 articles about 2-(4-chlorophenyl)-6-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + 4-chlorobenzoylmethyl bromide (536-38-9) → 2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine (103844-28-6)

Guidance literature:

With sodium hydrogencarbonate; In methanol; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.202000616

Reference yield: 81.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine (103844-28-6)

Guidance literature:

para-chloroacetophenone; With 1-butyl-3-methylimidazolium tribromide; In neat (no solvent); at 30 ℃; for 0.0833333h;

(5-methyl-pyridin-2-yl)amine; With sodium carbonate; In neat (no solvent); at 30 ℃; for 0.666667h;

DOI:10.3390/molecules171113368

Reference yield: 77.0%

5-methyl-2-pyridone (1003-68-5) + para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-6-methylimidazolo[1,2-a]pyridine (103844-28-6)

Guidance literature:

With O-tosylhydroxylamine; copper(II) bis(trifluoromethanesulfonate); 1-butyl-3-methylimidazolium Tetrafluoroborate; at 110 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

DOI:10.1039/c5ra09025c

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

4-chlorobenzoylmethyl bromide

para-chloroacetophenone

5-methyl-2-pyridone

Downstream raw materials:

2-(4-chlorophenyl)-6-methyl-3-(phenylthio)imidazo[1,2-α]pyridine

Refernces

• 1、 Silva, Daniel G.,Junker, Anna,de Melo, Shaiani M. G.,Fumagalli, Fernando,Gillespie, J. Robert,Molasky, Nora,Buckner, Frederick S.,Matheeussen, An,Caljon, Guy,Maes, Louis,Emery, Flavio S.. "Synthesis and Structure?Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases". supporting information. p. 966 - 975. Retrieved 2020/12/04.
• 2、 -. "Application of Imidazopyridine Derivatives in Regenerative Medicine". Paragraph 0010; 0237; 0239; 0241. . Retrieved 2020/03/09.