Carbamic acid, [1-[[(4-acetylphenyl)amino]carbonyl]-5-[[(phenylmethoxy)carbonyl]amino] pentyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [1-[[(4-acetylphenyl)amino]carbonyl]-5-[[(phenylmethoxy)carbonyl]amino] pentyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:103892-15-5
Molecular Formula:C27H35N3O6
Molecular Weight:497.591
Hs Code.:
Mol file:103892-15-5.mol

Synonyms:

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Chemical Property of Carbamic acid, [1-[[(4-acetylphenyl)amino]carbonyl]-5-[[(phenylmethoxy)carbonyl]amino] pentyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Carbamic acid, [1-[[(4-acetylphenyl)amino]carbonyl]-5-[[(phenylmethoxy)carbonyl]amino] pentyl]-, 1,1-dimethylethyl ester, (S)-

There total 1 articles about Carbamic acid, [1-[[(4-acetylphenyl)amino]carbonyl]-5-[[(phenylmethoxy)carbonyl]amino] pentyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 2389-45-9
Boc-Lys(Z)-OH

: 99-92-3
p-aminobenzophenone

: 103892-15-5
[(S)-5-(4-Acetyl-phenylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 4 ℃; for 18h;
DOI:10.1248/cpb.36.1289

Reference yield:

: 103892-15-5
[(S)-5-(4-Acetyl-phenylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester

: 116194-06-0
(S)-6-Amino-2-[(S)-2-((R)-2-amino-3-methyl-pentanoylamino)-3-phenyl-propionylamino]-hexanoic acid (4-acetyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / dioxane

2: 78 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

3: HCl / dioxane

4: 60 percent / HOBt, Et₃N, DCC / dimethylformamide / 1.) -15 deg C, 1 h; 2.) 4 deg C, 18 h

5: 47 percent / Pd / methanol

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.1289

Reference yield:

: 103892-15-5
[(S)-5-(4-Acetyl-phenylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester

: 103892-58-6
4-Aminomethyl-cyclohexanecarboxylic acid [(S)-1-(4-acetyl-phenylcarbamoyl)-5-amino-pentyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 5.5 N HCl / dioxane

2: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

3: 66.3 percent / H₂ / Pd / dimethylformamide

With hydrogenchloride; hydrogen; triethylamine; palladium; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2340