N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine

Base Information

• Chemical Name: N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine
• CAS No.: 112675-52-2
• Molecular Formula: C₁₈H₁₄N₆
• Molecular Weight: 314.349
• Mol file: 112675-52-2.mol

Synonyms:N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine

Chemical Property of N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine

Chemical Property:

• Vapor Pressure: 5.36E-14mmHg at 25°C
• Boiling Point: 592.2°Cat760mmHg
• Flash Point: 312°C
• PSA: 68.52000
• Density: 1.29g/cm³
• LogP: 3.54090

Purity/Quality:

N-(3-(1H-IMIDAZOL-1-YL)PHENYL)-4-(2-PYRIDINYL)-2-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine

There total 6 articles about N-(3-(1H-imidazol-1-yl)phenyl)-4-(2-pyridinyl)-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propan-1-ol (71-23-8) + (2E)-3-(dimethylamino)-1-(2-pyridyl)prop-2-en-1-one (66521-54-8,75415-00-8,123367-25-9) + 3-(1H-imidazol-1-yl)aniline (112677-67-5) → N-<3-(1H-imidazol-1-yl)phenyl>-4-(2-pyridinyl)-2-pyrimidinamine (112675-52-2)

Guidance literature:

With sodium hydroxide; In diethyl ether; water;

Reference yield:

3-fluoro-1-nitrobenzene (402-67-5) → N-<3-(1H-imidazol-1-yl)phenyl>-4-(2-pyridinyl)-2-pyrimidinamine (112675-52-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / K₂CO₃ / dimethylsulfoxide / 25.5 h / 105 - 110 °C

2: 96 percent / H₂ / PtO₂ / ethanol

3: 10 N aq. HCl / 0.25 h / Heating

4: K₂CO₃ / 2-methoxy-ethanol / 25 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; 2-methoxy-ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00071a002

Reference yield:

1-(3-nitrophenyl)-1H-imidazole (23309-09-3) → N-<3-(1H-imidazol-1-yl)phenyl>-4-(2-pyridinyl)-2-pyrimidinamine (112675-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / PtO₂ / ethanol

2: 10 N aq. HCl / 0.25 h / Heating

3: K₂CO₃ / 2-methoxy-ethanol / 25 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; 2-methoxy-ethanol;

DOI:10.1021/jm00071a002

upstream raw materials:

(Z)-3-(dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

3-fluoro-1-nitrobenzene

1-(3-nitrophenyl)-1H-imidazole

3-(1H-imidazol-1-yl)aniline