2,4-dimethoxybenzohydrazide

Base Information

• Chemical Name: 2,4-dimethoxybenzohydrazide
• CAS No.: 103956-10-1
• Molecular Formula: C9H12N2O3
• Molecular Weight: 196.206
• Mol file: 103956-10-1.mol

Synonyms:Benzoic acid,2,4-dimethoxy-,hydrazide;2,4diMeOPhCON2;

Chemical Property of 2,4-dimethoxybenzohydrazide

Chemical Property:

• PSA: 77.07000
• LogP: 1.58240

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dimethoxybenzohydrazide

There total 3 articles about 2,4-dimethoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

methyl 2, 4-dimethoxybenzoate (2150-41-6) → 2,4-dimethoxybenzohydrazide (103956-10-1)

Guidance literature:

With hydrazine hydrate; In methanol; for 6h; Reflux;

DOI:10.1016/j.bmc.2015.06.060

Reference yield:

2,4 dimethoxybenzoic acid (91-52-1) → 2,4-dimethoxybenzohydrazide (103956-10-1)

Guidance literature:

Multistep reaction; (i) MeOH, aq. HCl, CHCl₃, (ii) N₂H₄;

DOI:10.1021/jm00331a021

Reference yield:

4-methoxymethylsalicylate (5446-02-6) → 2,4-dimethoxybenzohydrazide (103956-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / Reflux

1.2: 8 h / 10 °C / Reflux

2.1: hydrazine hydrate / ethanol / 12 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1007/s11094-021-02459-0

upstream raw materials:

2,4 dimethoxybenzoic acid

methyl 2, 4-dimethoxybenzoate

4-methoxymethylsalicylate

Downstream raw materials:

3-(2,4-dimethoxy-phenyl)-5,6-diphenyl-[1,2,4]triazine

Refernces

• 1、 Al-Mansury, Sadiq,Balakit, Asim A.,Alkazazz, Fatin Fadhel,Ghaleb, Rana A.. "Synthesis, Antiproliferative and Antioxidant Activity of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogues". . p. 556 - 565. Retrieved 2021/09/28.
• 2、 -. "PROCESS OF MAKING CHALCOME DERIVATIVES". Page 116-117. . Retrieved 2010/02/07.