Acetamide, N-methyl-N-(2-methylphenyl)-

Base Information

• Chemical Name: Acetamide, N-methyl-N-(2-methylphenyl)-
• CAS No.: 573-26-2
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• European Community (EC) Number: 209-353-7
• NSC Number: 7648
• DSSTox Substance ID: DTXSID0060353
• Nikkaji Number: J95.019J
• Wikidata: Q81989082
• Mol file: 573-26-2.mol

Synonyms:573-26-2;Acetamide, N-methyl-N-(2-methylphenyl)-;N-Methyl-N-(2-methylphenyl)acetamide;Acetamide,N-methyl-N-(2-methylphenyl)-;o-Acetotoluidide, N-methyl-;NSC 7648;EINECS 209-353-7;AI3-10038;NSC7648;N-Methyl-O-acetotoluidide;N-Methyl-N-benzylacetamide;Acetamide, N-benzyl-N-methyl-;N-Methyl-N-(o-tolyl)acetamide;SCHEMBL5042970;DTXSID0060353;N-Methyl-N-(phenylmethyl)acetamide;NSC-7648;AKOS013918260;Acetamide, N-methyl-N-(phenylmethyl)-;F78499

Chemical Property of Acetamide, N-methyl-N-(2-methylphenyl)-

Chemical Property:

• Melting Point: 55.5°C
• Refractive Index: 1.5718 (estimate)
• Boiling Point: 290.31°C (rough estimate)
• PKA: 1.22±0.50(Predicted)
• PSA: 20.31000
• Density: 1.0508 (rough estimate)
• LogP: 1.97770
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1N(C)C(=O)C

Technology Process of Acetamide, N-methyl-N-(2-methylphenyl)-

There total 11 articles about Acetamide, N-methyl-N-(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-methylphenyl)acetamide (120-66-1) + dimethyl sulfate (77-78-1) → N-methyl-N-(2-methylphenyl)acetamide (573-26-2) + N,2-dimethylaniline (611-21-2)

Guidance literature:

With hexamethylenetetramine hydrobromide; potassium carbonate; In benzene; at 8 - 10 ℃; for 0.75h;

DOI:10.1080/00397919208021146

Reference yield: 88.0%

→ N-methyl-N-(2-methylphenyl)acetamide (573-26-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 140 ℃; for 20h; under 760.051 Torr;

Reference yield: 70.0%

N,N-dimethyl-o-toluidine (609-72-3) + acetic anhydride (108-24-7) → N-methyl-N-(2-methylphenyl)acetamide (573-26-2)

Guidance literature:

With oxygen; copper diacetate; In acetonitrile; for 36h; Schlenk technique; Sealed tube; Reflux;

DOI:10.1039/c5cc07454a

upstream raw materials:

acetic anhydride

N,2-dimethylaniline

N-(2-methylphenyl)acetamide

methyl iodide

Downstream raw materials:

4'-bromo-2'-methylacetanilide

4-bromo-N-bromoacetyl-N-methyl-2-tribromomethylaniline

N-ethyl-N-methyl-2-methylaniline

N,2-dimethylaniline

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