Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane

Base Information

• Chemical Name: Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane
• CAS No.: 104108-09-0
• Molecular Formula: C22H31P
• Molecular Weight: 326.462
• DSSTox Substance ID: DTXSID30543071
• Mol file: 104108-09-0.mol

Synonyms:104108-09-0;Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane;SCHEMBL16308831;DTXSID30543071

Chemical Property of Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane

Chemical Property:

• XLogP3: 6.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 5
• Exact Mass: 326.216337987
• Heavy Atom Count: 23
• Complexity: 322

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)P(C)C2=CC=CC=C2)C(C)C

Technology Process of Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane

There total 3 articles about Methyl(phenyl)[2,4,6-tri(propan-2-yl)phenyl]phosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

iodobenzene (591-50-4) + PHMe(Is) (158748-69-7) → Methyl-phenyl-(2,4,6-triisopropyl-phenyl)-phosphane (104108-09-0)

Guidance literature:

With sodium trimethylsilanolate; Pd-((R,R)-Me-Duphos)(Ph)(I); In tetrahydrofuran; toluene; at 21 ℃; for 2h;

DOI:10.1021/ja0267324

Reference yield: 89.0%

1,3,5-Triisopropyl-2-(methyl-phenyl-phosphinoyl)-benzene (104108-08-9) → Methyl-phenyl-(2,4,6-triisopropyl-phenyl)-phosphane (104108-09-0)

Guidance literature:

With lithium aluminium tetrahydride; cerium(III) chloride; In tetrahydrofuran; at 40 ℃; for 0.5h;

DOI:10.1246/cl.1985.1491

Reference yield:

methyldichlorophosphane (676-83-5) + phenylmagnesium bromide + (2,4,6-triisopropylphenyl)magnesium bromide (108894-99-1) → Methyl-phenyl-(2,4,6-triisopropyl-phenyl)-phosphane (104108-09-0) + PHMe(Is) (158748-69-7)

Guidance literature:

methyldichlorophosphane; (2,4,6-triisopropylphenyl)magnesium bromide; In diethyl ether; at -78 ℃;

phenylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ja0267324

upstream raw materials:

1,3,5-Triisopropyl-2-(methyl-phenyl-phosphinoyl)-benzene

iodobenzene

PHMe(Is)

methyldichlorophosphane