1,2-Hydrazinedicarboxylic acid, 1-(carboxyphenylmethyl)-, bis(1,1-dimethylethyl) ester, (S)-

Base Information

• Chemical Name: 1,2-Hydrazinedicarboxylic acid, 1-(carboxyphenylmethyl)-, bis(1,1-dimethylethyl) ester, (S)-
• CAS No.: 104267-05-2
• Molecular Formula: C18H26N2O6
• Molecular Weight: 366.414
• Mol file: 104267-05-2.mol

Synonyms:

Chemical Property of 1,2-Hydrazinedicarboxylic acid, 1-(carboxyphenylmethyl)-, bis(1,1-dimethylethyl) ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Hydrazinedicarboxylic acid, 1-(carboxyphenylmethyl)-, bis(1,1-dimethylethyl) ester, (S)-

There total 1 articles about 1,2-Hydrazinedicarboxylic acid, 1-(carboxyphenylmethyl)-, bis(1,1-dimethylethyl) ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3(2S),4S)-3-{2-[N,N'-bis-(t-butoxycarbonyl)hydrazino]phenylacetyl}-4-(phenylmethyl)-2-oxazolidinone (104266-95-7) → C18H26N2O6 (104267-05-2) + C18H26N2O6

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00280a050

Reference yield:

C18H26N2O6 (104267-05-2) → 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester (70363-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1.) CH₂Cl₂, 25 degC, 30 min

2: hydrogen; triethylamine / nickel / 1.) 550 psi, 4 h, 25 degC; 2.) CH₂Cl₂, 25 degC, 3 h

With hydrogen; triethylamine; trifluoroacetic acid; nickel;

DOI:10.1021/ja00280a050

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + C18H26N2O6 (104267-05-2) → (S)-Hydrazino-phenyl-acetic acid methyl ester (104267-13-2)

Guidance literature:

With trifluoroacetic acid; Multistep reaction; 1.) CH₂Cl₂, 25 degC, 30 min;

DOI:10.1021/ja00280a050

upstream raw materials:

(3(2S),4S)-3-{2-[N,N'-bis-(t-butoxycarbonyl)hydrazino]phenylacetyl}-4-(phenylmethyl)-2-oxazolidinone

Downstream raw materials:

(S)-Hydrazino-phenyl-acetic acid methyl ester

2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester