2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester

Base Information

• Chemical Name: 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester
• CAS No.: 70363-21-2
• Molecular Formula: C₁₉H₁₈F₃NO₄
• Molecular Weight: 381.351
• Mol file: 70363-21-2.mol

Synonyms:2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester

Chemical Property of 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester

There total 7 articles about 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-benzyl-3-phenylacetyl-2-oxazolidinone (104266-89-9) → 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester (70363-21-2)

Guidance literature:

Multi-step reaction with 4 steps

2: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

3: trifluoroacetic acid / 1.) CH₂Cl₂, 25 degC, 30 min

4: hydrogen; triethylamine / nickel / 1.) 550 psi, 4 h, 25 degC; 2.) CH₂Cl₂, 25 degC, 3 h

With lithium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; nickel; In tetrahydrofuran; water;

DOI:10.1021/ja00280a050

Reference yield:

(3(2S),4S)-3-{2-[N,N'-bis-(t-butoxycarbonyl)hydrazino]phenylacetyl}-4-(phenylmethyl)-2-oxazolidinone (104266-95-7) → 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester (70363-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

2: trifluoroacetic acid / 1.) CH₂Cl₂, 25 degC, 30 min

3: hydrogen; triethylamine / nickel / 1.) 550 psi, 4 h, 25 degC; 2.) CH₂Cl₂, 25 degC, 3 h

With lithium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; nickel; In tetrahydrofuran; water;

DOI:10.1021/ja00280a050

Reference yield:

C18H26N2O6 (104267-05-2) → 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester (70363-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1.) CH₂Cl₂, 25 degC, 30 min

2: hydrogen; triethylamine / nickel / 1.) 550 psi, 4 h, 25 degC; 2.) CH₂Cl₂, 25 degC, 3 h

With hydrogen; triethylamine; trifluoroacetic acid; nickel;

DOI:10.1021/ja00280a050

upstream raw materials:

diazomethane

(R)-methoxytrifluoromethylphenylacetyl chloride

2S-(N,N'-bis-(t-butoxycarbonyl)hydrazino)phenylacetic acid, methyl ester

(S)-4-benzyl-3-phenylacetyl-2-oxazolidinone