Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester
CAS No.:104293-55-2
Molecular Formula:C18H25NO4
Molecular Weight:319.401
Hs Code.:
Mol file:104293-55-2.mol

Synonyms:

Suppliers and Price of Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 133333-27-4
tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate

: 74-88-4
methyl iodide

: 104293-55-2
(3R,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 0.5h; Further stages.;
DOI:10.1021/jm0101803

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 104293-55-2
(3R,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / sulfur trioxide, pyridine, triethylamine, DMSO / CH₂Cl₂ / 1 h / 0 °C

2: 1.) chlorotitanium triisopropoxide / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, a.) -78 deg C, 15 min, b.) 0 deg C, 30 min

3: 100 mg / H₂ / 10percent Pd/C / ethyl acetate / 24 h

4: xylene / 14 h / Heating

With pyridine; triisopropoxytitanium(IV) chloride; sulfur trioxide; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; xylene;
DOI:10.1021/jo00371a001

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 104293-55-2
(3R,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) chlorotitanium triisopropoxide / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, a.) -78 deg C, 15 min, b.) 0 deg C, 30 min

2: 100 mg / H₂ / 10percent Pd/C / ethyl acetate / 24 h

3: xylene / 14 h / Heating

With triisopropoxytitanium(IV) chloride; hydrogen; palladium on activated charcoal; In ethyl acetate; xylene;
DOI:10.1021/jo00371a001