5α-Cholestan-6-one

Base Information

• Chemical Name: 5α-Cholestan-6-one
• CAS No.: 570-46-7
• Molecular Formula: C27H46O
• Molecular Weight: 386.662
• Mol file: 570-46-7.mol

Synonyms:Cholestan-6-one;

Chemical Property of 5α-Cholestan-6-one

Chemical Property:

• Vapor Pressure: 2.16E-08mmHg at 25°C
• Boiling Point: 452.9°C at 760 mmHg
• Flash Point: 219.3°C
• PSA: 17.07000
• Density: 0.953g/cm³
• LogP: 7.67680

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5α-Cholestan-6-one

There total 74 articles about 5α-Cholestan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-nitrocholest-5-ene (1912-53-4) → 5α-cholestan-6-one (570-46-7)

Guidance literature:

With acetic acid; zinc; In water; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/jacs.7b00335

Reference yield: 70.0%

6-nitrocholest-5-ene (1912-53-4) → 5α-cholestan-6-one (570-46-7) + 5-hydroxy-5α-cholestan-6-one (19043-54-0)

Guidance literature:

tin(ll) chloride; In tetrahydrofuran; for 0.25h; microwave irradiation;

Reference yield: 28.0%

Cholestane-5α,6α-diol (566-30-3) → 5α-cholestan-6-one (570-46-7) + 5β-cholestane-6-one (13713-79-6) + Cholest-4-en-6α-ol (15223-01-5)

Guidance literature:

With 3 A molecular sieve; thiamine diphosphate; diethylazodicarboxylate; In benzene; at 80 ℃; for 15h;

DOI:10.1007/BF00905072

upstream raw materials:

cholest-4-en-6-one

5-chloro-5α-cholestan-6-one

3β-iodo-5α-cholestan-6-one

6-nitrocholest-5-ene

Downstream raw materials:

6-hydroxyimino-5α-cholestane

5,6-seco-5-oxo-cholestan-6-oic acid

6,7-seco-5α-cholestane-6,7-dioic acid

6-iodo-5,6-seco-B-nor-5α-cholestan-5β-ol

Refernces

• 1、 Pitts, Cody Ross,Bume, Desta Doro,Harry, Stefan Andrew,Siegler, Maxime A.,Lectka, Thomas. "Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives". supporting information. p. 2208 - 2211. Retrieved 2017/02/23.
• 2、 Mushfiq,Khan,Shamim, Afreen,Rehman, Rakhshanda. "Synthesis of acylated steroidal olefins and their derivatives". scheme or table. p. 1508 - 1515. Retrieved 2010/07/15.