1-Hexanol, 6-[(4-methoxyphenyl)methoxy]-

Base Information

• Chemical Name: 1-Hexanol, 6-[(4-methoxyphenyl)methoxy]-
• CAS No.: 105192-33-4
• Molecular Formula: C14H22O3
• Molecular Weight: 238.327
• DSSTox Substance ID: DTXSID30444776
• Nikkaji Number: J1.229.831E
• Wikidata: Q82263036
• Mol file: 105192-33-4.mol

Synonyms:1-Hexanol, 6-[(4-methoxyphenyl)methoxy]-;105192-33-4;DTXSID30444776;6-(4-Methoxybenzyloxy)-1-hexanol

Chemical Property of 1-Hexanol, 6-[(4-methoxyphenyl)methoxy]-

Chemical Property:

• Boiling Point: 353.7±27.0 °C(Predicted)
• PSA: 38.69000
• Density: 1.024±0.06 g/cm3(Predicted)
• LogP: 2.76450
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 238.15689456
• Heavy Atom Count: 17
• Complexity: 165

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COCCCCCCO

Technology Process of 1-Hexanol, 6-[(4-methoxyphenyl)methoxy]-

There total 8 articles about 1-Hexanol, 6-[(4-methoxyphenyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Formic acid 6-(4-methoxy-benzyloxy)-hexyl ester → 6-<(4-methoxyphenyl)methoxy>hexan-1-ol (105192-33-4)

Guidance literature:

With aluminum oxide; In methanol; dichloromethane;

Reference yield: 92.0%

1,6-hexanediol (629-11-8) + p-methoxybenzyl chloride (824-94-2) → 6-<(4-methoxyphenyl)methoxy>hexan-1-ol (105192-33-4)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.202100571

Reference yield: 89.0%

1-({[6-(benzyloxy)hexyl]oxy}methyl)-4-methoxybenzene → 6-benzyloxyhexan-1-ol (71126-73-3) + 6-<(4-methoxyphenyl)methoxy>hexan-1-ol (105192-33-4)

Guidance literature:

1-({[6-(benzyloxy)hexyl]oxy}methyl)-4-methoxybenzene; With sodium hydrogencarbonate; bis-[(trifluoroacetoxy)iodo]benzene; meso-2,5-bis(methoxycarbonyl)-2,5-dimethylpyrrolidine-1-oxyl; In dichloromethane; at 20 ℃; for 2h;

With water; In dichloromethane; chemoselective reaction;

DOI:10.1021/acs.orglett.0c01839

upstream raw materials:

1,6-hexanediol

p-Methoxybenzyl bromide

p-methoxybenzyl chloride

{4-[({6-[(4-methoxybenzyl)oxy]hexyl}oxy)methyl]benzyl}trimethylsilane

Downstream raw materials:

4-methoxy-1-(6-phenylcarbonyloxyhexyloxymethyl)benzene

{4-[({6-[(4-methoxybenzyl)oxy]hexyl}oxy)methyl]benzyl}trimethylsilane

6-hydroxyhexyl benzoate

methyl (5S)-5-methoxymethoxy-12-p-methoxybenzyloxydodecanoate