71126-73-3Relevant articles and documents
A selective and efficient demesylation using methylmagnesium bromide
Cossy,Ranaivosata,Bellosta,Wietzke
, p. 3109 - 3112 (1995)
The chemoselective regeneration of alcohols from mesylates was accomplished by using methylmagnesium bromide in THF.
Stereoselective total synthesis of siladenoserinols A and D
Liu, Yinxin,Liu, Jun,Zhao, Chuanfang,Du, Yuguo
supporting information, p. 3264 - 3268 (2021/05/04)
The stereoselective total synthesis of siladenoserinols A and D has been accomplished using carbohydrate as a chiral template. The feature of this work is to build the medicinally privileged 6,8-DOBCO scaffold through a cascade reaction of hydrogenation/deacetalization/ketalization in a one-pot process, that is, to take advantage of a thermodynamically controlled bicyclization of polyhydroxyketone under HCl/MeOH reaction conditions. The current cost-effective synthetic strategy could facilitate the bioactivity investigation of siladenoserinols.
Radiosynthesis of novel N-18F-labeled 18F-FHex-α-l-Glu and 18F-FHex-β-Glu
Wen, Fuhua,Liu, Shaoyu,Ma, Hui,Tang, Ganghua
, p. 222 - 230 (2020/04/02)
N-18F-labeled amino acids are important substitutes for new positron emission tomography (PET) imaging tracers complementing the deficiency of 18F-fluorodeoxyglucose (18F-FDG). In this work, two novel N-6-18F-alkyl amino acid imaging agents, 18F-FHex-α-l-Glu and 18F-FHex-β-Glu, were designed and synthesized as potential probes for PET imaging of tumors. 18F-FHex-α-l-Glu was synthesized using the precursor 6 from 18F-F? with the yield of 16 ± 4% (n = 5, uncorrected) within about 50 minutes. The specific activity was 14.5 GBq/μmol, and the radiochemical purity was more than 95%. 18F-FHex-β-Glu was synthesized using the precursor 12 based on 18F-F? with the yield of 11 ± 3% (n = 3, uncorrected) in about 60 minutes. The specific activity was 9.1 GBq/μmol, and the radiochemical purity was more than 95%.
