ethyl 2-[(anilinocarbonyl)amino]-5-phenyl-3-thiophenecarboxylate

Base Information

• Chemical Name: ethyl 2-[(anilinocarbonyl)amino]-5-phenyl-3-thiophenecarboxylate
• CAS No.: 106666-45-9
• Molecular Formula: C20H18N2O3S
• Molecular Weight: 366.43400
• Mol file: 106666-45-9.mol

Synonyms:

Chemical Property of ethyl 2-[(anilinocarbonyl)amino]-5-phenyl-3-thiophenecarboxylate

Chemical Property:

• PSA: 95.67000
• LogP: 5.38180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[(anilinocarbonyl)amino]-5-phenyl-3-thiophenecarboxylate

There total 4 articles about ethyl 2-[(anilinocarbonyl)amino]-5-phenyl-3-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H12ClNO3S + aniline (62-53-3) → ethyl 5-phenyl-2-(3-phenylureido)thiophene-3-carboxylate (106666-45-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2020.112772

Reference yield:

ethyl 2-amino-5-phenylthiophene-3-carboxylate (4815-34-3) → ethyl 5-phenyl-2-(3-phenylureido)thiophene-3-carboxylate (106666-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1016/j.ejmech.2020.112772

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl 5-phenyl-2-(3-phenylureido)thiophene-3-carboxylate (106666-45-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfur; diethylamine / ethanol / 14 h / 20 °C

2: toluene / 12 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sulfur; diethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; toluene;

DOI:10.1016/j.ejmech.2020.112772

upstream raw materials:

ethyl 2-amino-5-phenylthiophene-3-carboxylate

ethyl 2-cyanoacetate

phenylacetaldehyde

aniline

Refernces