2-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodec ahydrocyclopenta[a]phenanthren-3-one

Base Information

• Chemical Name: 2-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodec ahydrocyclopenta[a]phenanthren-3-one
• CAS No.: 1649-24-7
• Molecular Formula: C₁₉H₂₇FO₂
• Molecular Weight: 306.421
• Mol file: 1649-24-7.mol

Synonyms:Androst-4-en-3-one,2a-fluoro-17b-hydroxy- (7CI,8CI);Testosterone, 2a-fluoro-(6CI); 2a-Fluoro-17b-hydroxyandrost-4-en-3-one; 2a-Fluorotestosterone; NSC 41843

Chemical Property of 2-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodec ahydrocyclopenta[a]phenanthren-3-one

Chemical Property:

• Vapor Pressure: 2.88E-09mmHg at 25°C
• Melting Point: 140-141 °C
• Boiling Point: 431.8°Cat760mmHg
• PKA: 15.00±0.70(Predicted)
• Flash Point: 214.9°C
• PSA: 37.30000
• Density: 1.16g/cm³
• LogP: 3.82720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodec ahydrocyclopenta[a]phenanthren-3-one

There total 9 articles about 2-fluoro-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodec ahydrocyclopenta[a]phenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2α-fluorotestosterone (1649-24-7)

Guidance literature:

With perchloryl fluoride; sodium methylate; benzene; Erwaermen des Reaktionsprodukts mit Kaliumacetat in Methanol;

DOI:10.1021/ja01528a061

Reference yield:

testosterone (58-22-0) → 2α-fluorotestosterone (1649-24-7)

Guidance literature:

With oxalic acid diethyl ester; Aufeinanderfolgende Umsetzung mit ClO₃F und mit Natriummethylat in Methanol;

DOI:10.1021/ja01491a038

Reference yield:

→ 2α-fluorotestosterone (1649-24-7)

Guidance literature:

With ethanol; chloroform; hydrogen fluoride;

DOI:10.1139/v74-430

upstream raw materials:

testosterone