6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Base Information

Chemical Name:6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid
CAS No.:77628-52-5
Molecular Formula:C12H8N2O2S
Molecular Weight:244.274
Hs Code.:2934100090
NSC Number:315238
DSSTox Substance ID:DTXSID00317403
Nikkaji Number:J277.614F
Wikidata:Q82072135
Mol file:77628-52-5.mol

Synonyms:77628-52-5;6-phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid;6-Phenylimidazo[2,1-b]thiazole-5-carboxylic acid;NSC315238;Imidazo[2,1-b]thiazole-5-carboxylic acid, 6-phenyl-;SCHEMBL22761661;DTXSID00317403;AKOS000345359;MB04010;NSC 315238;NSC-315238;CS-0455644;FT-0741399;6-Phenylimidazo[2,1-b]thiazole-5-carboxylicacid;EN300-7441719

Suppliers and Price of 6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Phenylimidazo[2,1-b]thiazole-5-carboxylicacid 95+%
1g
$ 535.00

American Custom Chemicals Corporation
6-PHENYLIMIDAZO(2,1-B)(1,3)THIAZOLE-5-CARBOXYLIC ACID 95.00%
5G
$ 3811.50

Alichem
6-Phenylimidazo[2,1-b]thiazole-5-carboxylicacid
1g
$ 440.36

Total 14 raw suppliers

Chemical Property of 6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

Chemical Property:

Melting Point:155-156 °C (decomp)
PKA:-0.97±0.41(Predicted)
PSA：82.84000
Density:1.48g/cm³
LogP:2.76100
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:244.03064868
Heavy Atom Count:17
Complexity:307

Purity/Quality:

99% ^*data from raw suppliers

6-Phenylimidazo[2,1-b]thiazole-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(N3C=CSC3=N2)C(=O)O

Technology Process of 6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

There total 4 articles about 6-Phenylimidazo[2,1-b][1,3]thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

: 134670-22-7
6-Phenyl-5-trifluoroacetylimidazo<2,1-b>thiazole

: 77628-52-5
6-phenylimidazo<2,1-b>thiazole-5-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 - 40 ℃; for 20h;

Reference yield: 70.8%

: 127801-93-8
ethyl 6-phenylimidazo<2,1-b>thiazole-5-carboxylate

: 77628-52-5
6-phenylimidazo<2,1-b>thiazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 1h; Heating;
DOI:10.1016/0223-5234(96)88309-7

Reference yield:

: 55919-47-6
ethyl 2-bromo-3-oxo-3-phenylpropionate

: 77628-52-5
6-phenylimidazo<2,1-b>thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 23.4 percent / ethanol / 16 h / Heating

2: 70.8 percent / NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; In ethanol; water;
DOI:10.1016/0223-5234(96)88309-7