55919-47-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-bromo-3-oxo-3-phenylpropanoate is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its reactivity allows for the creation of new compounds with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Ethyl 2-bromo-3-oxo-3-phenylpropanoate serves as a precursor in the production of various agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Flavors and Fragrances Industry:
Ethyl 2-bromo-3-oxo-3-phenylpropanoate is utilized as a component in the creation of flavors and fragrances, capitalizing on its fruity odor to enhance the sensory qualities of various products.
However, it is crucial to handle Ethyl 2-bromo-3-oxo-3-phenylpropanoate with care due to its corrosive nature, which may cause irritation to the skin, eyes, and respiratory system if not properly managed.

InChI:InChI=1/C11H11BrO3/c1-2-15-11(14)9(12)10(13)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 128-08-5 N-Bromosuccinimide 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 504-29-0 2-aminopyridine 
• 4086-63-9 2-Benzylamino-6-aminotriazine 
• 98-86-2 acetophenone 
• 934-32-7 1H-benzimidazol-2-amine 
• 64-19-7 acetic acid 

Downstream Products

• 860744-60-1 3-oxo-3-phenyl-2,2-dipiperidino-propionic acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 71-43-2 benzene 
• 13950-67-9 ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate 
• 99822-80-7 ethyl 4-phenyl-1,3-thiazole-5-carboxylate 
• 127801-93-8 ethyl 6-phenylimidazo<2,1-b>thiazole-5-carboxylate 
• 127801-97-2 ethyl 2-benzoylimino-2,3-dihydrothiazole-3-acetate 
• 119448-82-7 ethyl 2-phenylimidazo[1,2-a] pyridine-3-carboxylate 
• 127801-89-2 ethyl 2-phenylimidazo<1,2-a>pyrimidine-3-carboxylate 
• 144294-13-3 ethyl 2-phenylimidazo<1,2-a>pyrazine-3-carboxylate 
• 87814-40-2 N-(pyrazin-2-yl)benzamide 
• 127801-87-0 ethyl 6-methyl-2-phenylimidazo[1,2-a]pyridine-3-carboxylate 
• 127801-92-7 ethyl 3-methyl-6-phenylimidazo<2,1-b>thiazole-5-carboxylate 
• 127801-96-1 ethyl 2-benzoylimino-2,3-dihydro-4-methylthiazole-3-acetate 

Relevant academic research and scientific papers

Electrochemical chlorination and bromination of electron-deficient C[sbnd]H bonds in quinones, coumarins, quinoxalines and 1,3-diketones

The electrochemistry-promoted chlorination and bromination of electron-deficient C[sbnd]H bonds was developed, using quinones, coumarins, quinoxalines and 1,3-diketones. This protocol features readily available and safe halogen sources (hydrochloric acid and KBr), high site-selectivity and mild reaction conditions. It could provide an efficient access to a series of chlorinated and brominated quinones, coumarins, quinoxalines and 1,3-diketones.

Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors

Herein we report a microscale parallel synthetic approach allowing for rapid access to libraries of N-acylated aminotriazoles and screening of their inhibitory activity against factor XIIa (FXIIa) and thrombin, which are targets for antithrombotic drugs. This approach, in combination with post-screening structure optimization, yielded a potent 7 nM inhibitor of FXIIa and a 25 nM thrombin inhibitor; both compounds showed no inhibition of the other tested serine proteases. Selected N-acylated aminotriazoles exhibited anticoagulant properties in vitro influencing the intrinsic blood coagulation pathway, but not extrinsic coagulation. Mechanistic studies of FXIIa inhibition suggested that synthesized N-acylated aminotriazoles are covalent inhibitors of FXIIa. These synthesized compounds may serve as a promising starting point for the development of novel antithrombotic drugs.

PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS

The present invention is directed to substituted Pyrazole and Imidazole derivatives of compounds that are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which

Highly efficient and green synthesis of 2,4-diphenyl substituted thiazoles

2,4-Diphenyl thiazole is an important organic intermediate and its derivatives contain multiple biological properties. In the present study, we reported a new protocol to synthesize 2,4-diphenyl thiazole analogs, which involved the bromination of ethyl benzoylacetates with NBS in the presence of 2-hydroxypropyl-β-cyclodextrin, followed by a direct cyclization with thiobenzamides in water. Compared with the reported method, the current protocol contains less reaction steps, milder reaction conditions, and simpler workup procedure.

Design, synthesis, and biological evaluation of novel imidazo[1,2-a]pyridinecarboxamides as potent anti-tuberculosis agents

Tuberculosis (TB) is a highly infectious disease that has been plaguing the human race for centuries. The emergence of multidrug-resistant strains of TB has been detrimental to the fight against tuberculosis with very few safe therapeutic options availabl

Synthesis of imidazo[1,2-a] [1,3,5]triazines by NBS-mediated coupling of 2-amino-1,3,5-triazines with 1,3-dicarbonyl compounds

Aroylimidazo[1,2-a][1,3,5]triazines are rapidly synthesized via a facile and mild reaction of 2-amino-triazines and 1,3-dicarbonyl compounds using NBS. The reaction occurred with good yields and excellent regioselectivity, and β-keto esters, β-keto amides, and 1,3-diones were tolerated under the optimized procedure. In addition, the successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.

An efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot

A metal-free one-pot method for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives was proposed mediated by CBr4. The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields.

Reaction of the C60 radical anion with alkyl halides

The reaction of the C60 radical anion (C60-) with α-bromo-1,3-dicarbonyl compounds selectively afforded the methanofullerene derivatives. The reaction with benzyl halide and 1,2-bis(dihalomethyl)benzene afforded the corresponding 1,4-dibenzylated C60 derivative and cycloaddition product, respectively. The possible mechanisms for the formation of the fullerene adducts are proposed.

Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation

We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions.

Electrochemically Induced Intermolecular Cross-Dehydrogenative C-O Coupling of β-Diketones and β-Ketoesters with Carboxylic Acids

The electrochemically induced cross-dehydrogenative C-O coupling of β-diketones and β-ketoesters (C-H reagents) with carboxylic acids (O-H reagents) was developed. An important feature of this reaction lies in the selective formation of intermolecular C-O