Phosphoric triamide,N,N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)-

Base Information

• Chemical Name: Phosphoric triamide,N,N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)-
• CAS No.: 27578-74-1
• Molecular Formula: C18H24 Cl2 N3 O3 P
• Molecular Weight: 432.2812
• Mol file: 27578-74-1.mol

Synonyms:Phosphorictriamide, N,N-bis(2-chloroethyl)-N',N''-bis(p-methoxyphenyl)- (8CI); NSC 93204

Chemical Property of Phosphoric triamide,N,N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphoric triamide,N,N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)-

There total 1 articles about Phosphoric triamide,N,N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + 4-methoxy-aniline (104-94-9) → N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)phosphotriamidate (27578-74-1)

Guidance literature:

With triethylamine; In dichloromethane; for 120h; Ambient temperature;

DOI:10.1055/s-1996-4364

Reference yield: 95.0%

N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)phosphotriamidate (27578-74-1) → [1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ5-[1,3,2]diazaphospholidin-2-yl]-(4-methoxy-phenyl)-amine (183055-98-3)

Guidance literature:

With sodium methylate; In methanol; for 24h; Ambient temperature;

DOI:10.1055/s-1996-4364

Reference yield:

N-bis(2-chloroethyl)-N',N''-bis(4-methoxyphenyl)phosphotriamidate (27578-74-1) → 1,7-Bis-(4-methoxy-phenyl)-tetrahydro-[1,3,2]diazaphospholo[1,2-a][1,3,2]diazaphosphole 8-oxide (183056-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaOMe / methanol / 24 h / Ambient temperature

2: 92 percent / NaH, Bu₄NBr / benzene / 5 h / Ambient temperature

With tetrabutylammomium bromide; sodium methylate; sodium hydride; In methanol; benzene;

DOI:10.1055/s-1996-4364

upstream raw materials:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride

4-methoxy-aniline

Downstream raw materials:

2-[bis-(2-chloro-ethyl)-amino]-1,3-bis-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidine-4,5-dione

[1-(2-Chloro-ethyl)-3-(4-methoxy-phenyl)-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-2-yl]-(4-methoxy-phenyl)-amine

1,7-Bis-(4-methoxy-phenyl)-tetrahydro-[1,3,2]diazaphospholo[1,2-a][1,3,2]diazaphosphole 8-oxide