1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione

Base Information

Chemical Name:1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione
CAS No.:108640-71-7
Molecular Formula:C17H15NO2
Molecular Weight:265.312
Hs Code.:
DSSTox Substance ID:DTXSID10552383
Wikidata:Q82432592
Mol file:108640-71-7.mol

Synonyms:108640-71-7;SCHEMBL5769842;1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione;DTXSID10552383

Suppliers and Price of 1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:265.110278721
Heavy Atom Count:20
Complexity:349

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1=O)CC2=CC=C(C=C2)C3=CC=CC=C3

Technology Process of 1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione

There total 2 articles about 1-[([1,1'-Biphenyl]-4-yl)methyl]pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

: 791817-72-6
1-(4-bromobenzyl)pyrrolidine-2,5-dione

: 98-80-6
phenylboronic acid

: 108640-71-7
1-(biphenyl-4-ylmethyl)pyrrolidine-2,5-dione

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; triethylamine; In tetrahydrofuran; for 24h; Heating;
DOI:10.1021/jm049559q

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 108640-71-7
1-(biphenyl-4-ylmethyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / acetic acid; 4-dimethylaminopyridine / 24 h / Heating

2: 58 percent / aq. palladium acetate; triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; triethylamine / tetrahydrofuran / 24 h / Heating

With dmap; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; acetic acid; triethylamine; In tetrahydrofuran; 2: Suzuki coupling;
DOI:10.1021/jm049559q