6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline

Base Information

Chemical Name:6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline
CAS No.:482-32-6
Molecular Formula:C13H9NO4
Molecular Weight:243.21
Hs Code.:
Mol file:482-32-6.mol

Synonyms:6-methoxy-[1,3]dioxolo[4,5-h]furo[2,3-b]quinoline;Kokusagin;6-Methoxy-[1,3]dioxolo[4,5-h]furo[2,3-b]chinolin;

Suppliers and Price of 6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline

Chemical Property:

Melting Point:194°C
PSA：53.72000
LogP:2.71830

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Terasaka has isolated this furoquinoline alkaloid from the roots of Orixa japonica and Obata has found that it also occurs in the fruit along with skim_x0002_mianine (q.v.). The alkaloid is optically inactive and is converted by Mel at 100°C into isokokusagine, m.p. 247°C. The aurichloride has m.p. 171°C and the picrate, m.p. 178°C (157°C according to Obata). The structure has been established by synthesis as 7: 8-methylenedioxydictamnine.

Technology Process of 6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline

There total 19 articles about 6-Methoxy-1,3-dioxolo[4,5-h]furo[2,3-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 74-97-5
chlorobromomethane

: 119188-51-1
4-methoxyfuro[2,3-b]quinoline-7,8-diol

: 482-32-6
kokusagine

Guidance literature:: With potassium carbonate; In acetone; for 20h; Heating;

Reference yield: 25.0%

: 74120-90-4
2,3-Dihydro-3-hydroxy-4-methoxy-7,8-methylenedioxyfuro<2,3-b>quinoline

: 482-32-6
kokusagine

Guidance literature:: With potassium hydrogensulfate; In tetrahydrofuran;
DOI:10.1080/00021369.1980.10863935

Reference yield:

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 482-32-6
kokusagine

Guidance literature:: Multi-step reaction with 9 steps

1: 67 percent / cupric oxide

2: 81 percent / KMnO₄

3: 2.) ammonium acetate

4: 46 percent / sodium hypochlorite

5: 1.) Na

6: paraffin / 0.17 h / 250 °C

7: 27 percent / dioxane; methanol

8: 59 percent / NaBH₄

9: 25 percent / KHSO₄ / tetrahydrofuran

With ammonium acetate; sodium hypochlorite; sodium tetrahydroborate; potassium permanganate; potassium hydrogensulfate; sodium; copper(II) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; paraffin;
DOI:10.1080/00021369.1980.10863935