5,7-diphenyl-2,3-dihydro-1H-pyrrolizine

Base Information

• Chemical Name: 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine
• CAS No.: 109028-59-3
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• DSSTox Substance ID: DTXSID10452697
• Nikkaji Number: J502.722E
• ChEMBL ID: CHEMBL143523
• Mol file: 109028-59-3.mol

Synonyms:5,7-diphenyl-2,3-dihydro-1H-pyrrolizine;CHEMBL143523;109028-59-3;DTXSID10452697;BDBM50094543;1,3-Diphenyl-6,7-dihydro-5H-pyrrolizine;5,7-diphenyl-1,2,3,4-tetrahydro-pyrrolizine

Chemical Property of 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 314

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=C(N2C1)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine

There total 7 articles about 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C19H19N → 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine (109028-59-3)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In toluene; for 8h; Reflux;

DOI:10.1039/c5cc03390j

Reference yield: 79.0%

pyrrolidine (123-75-1) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine (109028-59-3) + 1,3-diphenyl-3-(pyrrolidin-1-yl)prop-2-en-1-one (145800-06-2)

Guidance literature:

With silica gel; for 0.333333h; Irradiation;

DOI:10.1016/S0040-4039(00)60678-0

Reference yield: 65.0%

pyrrolidine (123-75-1) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → n-benzoylpyrrolidine (3389-54-6) + 5,7-diphenyl-2,3-dihydro-1H-pyrrolizine (109028-59-3)

Guidance literature:

In xylenes; at 280 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tetlet.2010.03.086

upstream raw materials:

pyrrolidine

1,3-diphenylpropanedione

1,3-diphenyl-propen-3-one

Downstream raw materials:

(5,7-Diphenyl-2,3-dihydro-1H-pyrrolizin-6-yl)-essigsaeureethylester