2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane

Base Information

Chemical Name:2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane
CAS No.:109202-00-8
Molecular Formula:C10H11ClO2
Molecular Weight:198.649
Hs Code.:
DSSTox Substance ID:DTXSID30547276
Mol file:109202-00-8.mol

Synonyms:2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane;109202-00-8;DTXSID30547276

Suppliers and Price of 2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:198.0447573
Heavy Atom Count:13
Complexity:178

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2(CO2)CCl

Technology Process of 2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane

There total 2 articles about 2-(Chloromethyl)-2-(4-methoxyphenyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₁₂Cl₂O₂

: 109202-00-8
2-(chloromethyl)-2-(p-methoxyphenyl)oxirane

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.201603210

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 109202-00-8
2-(chloromethyl)-2-(p-methoxyphenyl)oxirane

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; N,N-dimethyl-formamide; 1: |Grignard Reaction;
DOI:10.1002/anie.201603210