4-Methoxyphenylmagnesium bromide

Base Information

• Chemical Name: 4-Methoxyphenylmagnesium bromide
• CAS No.: 13139-86-1
• Molecular Formula: C7H7BrMgO
• Molecular Weight: 211.341
• Hs Code.: 29319090
• Mol file: 13139-86-1.mol

Synonyms:Magnesium,bromo(p-methoxyphenyl)- (7CI,8CI);p-Methoxyphenylmagnesium bromide (6CI);(4-Methoxyphenyl)magnesium bromide;(p-Anisyl)bromomagnesium;4-Anisylmagnesiumbromide;Bromo(4-methoxyphenyl)magnesium;Bromo(p-methoxyphenyl)magnesium;p-Anisylmagnesium bromide;

Chemical Property of 4-Methoxyphenylmagnesium bromide

Chemical Property:

• Appearance/Colour: Clear to brown solution when properly stored
• Boiling Point: 65-67 °C
• Flash Point: -4 °F
• PSA: 9.23000
• Density: 0.955 g/mL at 25 °C
• LogP: 2.34100
• Storage Temp.: Flammables + water-Freezer (-20°C)e area
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: Severe reaction

Purity/Quality:

99.9% ^*data from raw suppliers

4-Methoxyphenylmagnesium bromide, 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-14-19-22-34-14/15-40-37
• Safety Statements: 16-26-33-36/37/39-45-6A-43B

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxyphenylmagnesium bromide is applied in Grignard-reactions as a reagent for the introduction of the 4-methoxyphenyl group.

Technology Process of 4-Methoxyphenylmagnesium bromide

There total 9 articles about 4-Methoxyphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + magnesium (7439-95-4) → 4-methoxyphenyl magnesium bromide (13139-86-1)

Guidance literature:

With 1,2-dibromomethane; In tetrahydrofuran; at 40 ℃; for 1.5h;

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → 4-methoxyphenyl magnesium bromide (13139-86-1)

Guidance literature:

With magnesium; bromine; In diethyl ether;

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) + 7-chloro-1,2,3,4,4a,9b-hexahydro-2-methyl-5H-1,3-ethanoindeno-[1,2-c]pyridin-5-one (173433-59-5) → 7-Chloro-5-(p-methoxyphenyl)-2-methyl-1,3-ethano-1,2,3,4,4a,9b-hexahydro-5H-indeno[1,2-c]pyridin-5-ol (173434-18-9) + 4-methoxyphenyl magnesium bromide (13139-86-1)

Guidance literature:

With magnesium; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1-bromo-4-methoxy-benzene

7-chloro-1,2,3,4,4a,9b-hexahydro-2-methyl-5H-1,3-ethanoindeno-[1,2-c]pyridin-5-one

1,10-Phenanthroline

ethylene dibromide

Downstream raw materials:

2-methoxyphenethyl alcohol

2-(4-Methoxyphenyl)ethanol

5-(4-methoxyphenyl)pentan-1-al

2,2-bis(4-methoxyphenyl)tetrahydrofuran

Refernces

• 1、 Nienhouse. "-". . p. 101. Retrieved 1967.
• 2、 Liu, Yuxia,Wang, Chao,Huang, Linjuan,Xue, Dong. "Room-Temperature Palladium(II)-Catalyzed Direct 2-Arylation of Indoles with Tetraarylstannanes". supporting information. p. 1613 - 1618. Retrieved 2020/09/15.
• 3、 Li, Jie,Ren, Qianyi,Cheng, Xinyi,Karaghiosoff, Konstantin,Knochel, Paul. "Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents". supporting information. p. 18127 - 18135. Retrieved 2019/11/19.