N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE

Base Information

• Chemical Name: N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE
• CAS No.: 109567-63-7
• Molecular Formula: C₁₅H₁₁ClN₂O₃
• Molecular Weight: 302.717
• Mol file: 109567-63-7.mol

Synonyms:3-Nitro-trans-zimtsaeure-(3-chlor-anilid);(E)-N-(3-Chloro-phenyl)-3-(3-nitro-phenyl)-acrylamide;3-nitro-trans-cinnamic acid-(3-chloro-anilide);

Chemical Property of N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE

Chemical Property:

• Melting Point: 189 °C (ethanol)
• PSA: 74.92000
• LogP: 4.49630

Purity/Quality:

99% ^*data from raw suppliers

N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE

There total 3 articles about N-(3-CHLOROPHENYL)-3-(3-NITROPHENYL)ACRYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-nitrocinnamic acid chloride (35418-05-4,141236-48-8) + 3-chloro-aniline (108-42-9) → (E)-N-(3-chlorophenyl)-3-(3-nitrophenyl)-prop-2-enamide (109567-63-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 5 - 20 ℃;

DOI:10.1021/jm500547c

Reference yield:

(E)-3-Nitrocinnamic acid (555-68-0,1772-76-5) → (E)-N-(3-chlorophenyl)-3-(3-nitrophenyl)-prop-2-enamide (109567-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 55 °C / Reflux

2: triethylamine / tetrahydrofuran / 5 - 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm500547c

Reference yield:

→ (E)-N-(3-chlorophenyl)-3-(3-nitrophenyl)-prop-2-enamide (109567-63-7)

Guidance literature:

/BRN= 3135653/;

upstream raw materials:

(E)-3-Nitrocinnamic acid

(E)-3-nitrocinnamic acid chloride

3-chloro-aniline

Downstream raw materials:

(E)-3-(3-aminophenyl)-N-(3-chlorophenyl)-prop-2-enamide

Refernces