L-Leucine, N-[[hydroxy[3-methyl-1-[[(phenylmethoxy)carbonyl]amino]butyl]phosphin yl]carbonyl]-, phenylmethyl ester, (R)-

Base Information

Chemical Name:L-Leucine, N-[[hydroxy[3-methyl-1-[[(phenylmethoxy)carbonyl]amino]butyl]phosphin yl]carbonyl]-, phenylmethyl ester, (R)-
CAS No.:109639-06-7
Molecular Formula:C₂₇H₃₇N₂O₇P
Molecular Weight:532.574
Hs Code.:
Mol file:109639-06-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Leucine, N-[[hydroxy[3-methyl-1-[[(phenylmethoxy)carbonyl]amino]butyl]phosphin yl]carbonyl]-, phenylmethyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of L-Leucine, N-[[hydroxy[3-methyl-1-[[(phenylmethoxy)carbonyl]amino]butyl]phosphin yl]carbonyl]-, phenylmethyl ester, (R)-

There total 6 articles about L-Leucine, N-[[hydroxy[3-methyl-1-[[(phenylmethoxy)carbonyl]amino]butyl]phosphin yl]carbonyl]-, phenylmethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109639-04-5,109717-01-3,109717-02-4,109717-03-5
C₂₈H₃₉N₂O₇P

: 109639-05-6,109639-06-7
C₂₇H₃₇N₂O₇P

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 22 ℃; for 5h;
DOI:10.1021/jm00392a014

Reference yield:

: 109638-99-5
(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

: 109639-05-6,109639-06-7
C₂₇H₃₇N₂O₇P

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / methanol; diethyl ether / 0.5 h / 22 °C

2: Et₃N / CH₂Cl₂ / 0.5 h

3: Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

4: Me₃SiBr / CH₂Cl₂; various solvent(s) / 5 h / 22 °C

With trimethylsilyl bromide; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00392a014

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 109639-05-6,109639-06-7
C₂₇H₃₇N₂O₇P

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 2.0 M aq. NaOH, NaHCO₃, Na₂CO₃ / 22 °C

2: 100 percent / methanol; diethyl ether / 0.5 h / 22 °C

3: Et₃N / CH₂Cl₂ / 0.5 h

4: Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

5: Me₃SiBr / CH₂Cl₂; various solvent(s) / 5 h / 22 °C

With sodium hydroxide; trimethylsilyl bromide; sodium hydrogencarbonate; sodium carbonate; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00392a014