2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one

Base Information

• Chemical Name: 2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one
• CAS No.: 109681-49-4
• Molecular Formula: C14H22OSi
• Molecular Weight: 234.40900
• DSSTox Substance ID: DTXSID50546589
• Nikkaji Number: J859.430I
• Wikidata: Q82424464
• Mol file: 109681-49-4.mol

Synonyms:109681-49-4;2-(TERT-BUTYLDIMETHYLSILYL)-1-PHENYLETHANONE;2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one;DTXSID50546589

Chemical Property of 2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one

Chemical Property:

• PSA: 17.07000
• LogP: 4.37780
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 234.143991855
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)CC(=O)C1=CC=CC=C1

Technology Process of 2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one

There total 19 articles about 2-[tert-Butyl(dimethyl)silyl]-1-phenylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethane-1,2-diol (109681-47-2) → 2-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethanone (109681-49-4)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 19h;

DOI:10.1016/S0040-4039(00)94249-7

Reference yield: 98.0%

phenylcerium dichloride (99354-16-2) + tert-butyldimethylsilylketene (104992-44-1) → 2-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethanone (109681-49-4)

Guidance literature:

In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

DOI:10.1248/cpb.45.1135

Reference yield:

[2-(tert-butyl-dimethyl-silanyl)-1-phenyl-ethylidene]-hydrazine (398487-04-2) → tert‐butyldimethyl(phenylethynyl)silane (85443-40-9) + 2-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethanone (109681-49-4) + 2-tert-butyldimethylsilyl-1-phenyldiazoethane (398487-05-3)

Guidance literature:

With manganese(IV) oxide; magnesium sulfate; In diethyl ether; at 20 ℃; for 1.33333h;

DOI:10.1021/jo0106546

upstream raw materials:

1-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethane-1,2-diol

phenylcerium dichloride

tert-butyldimethylsilylketene

((E)-2-tert-Butoxy-2-phenyl-vinyl)-tert-butyl-dimethyl-silane

Downstream raw materials:

2-tert-butyldimethylsilyl-1-phenyldiazoethane

tert‐butyldimethyl(phenylethynyl)silane

tert-butyl-dimethyl-(1-phenyl-vinyl)-silane

[2-(tert-butyl-dimethyl-silanyl)-1-phenyl-ethylidene]-hydrazine