Technology Process of 1-Butanol, 4,4,4-trifluoro-3-[(phenylthio)methyl]-, (S)-
There total 8 articles about 1-Butanol, 4,4,4-trifluoro-3-[(phenylthio)methyl]-, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / H2 / 5percent Pd-C / methanol
2: toluene / 6 h / Heating
3: Et3N / CH2Cl2 / 0 °C
4: NaH / tetrahydrofuran / Ambient temperature
5: c-HCl / acetic acid / 13 h / Heating
6: AcCl
7: DIBAL-H / diethyl ether / 0 °C
With
hydrogenchloride; hydrogen; sodium hydride; diisobutylaluminium hydride; triethylamine; acetyl chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 6 h / Heating
2: Et3N / CH2Cl2 / 0 °C
3: NaH / tetrahydrofuran / Ambient temperature
4: c-HCl / acetic acid / 13 h / Heating
5: AcCl
6: DIBAL-H / diethyl ether / 0 °C
With
hydrogenchloride; sodium hydride; diisobutylaluminium hydride; triethylamine; acetyl chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5
