2-Amino-1-phenylbutan-1-ol hydrochloride

Base Information

• Chemical Name: 2-Amino-1-phenylbutan-1-ol hydrochloride
• CAS No.: 6170-27-0
• Molecular Formula: C₁₀H₁₅NO*ClH
• Molecular Weight: 201.696
• NSC Number: 24527
• Mol file: 6170-27-0.mol

Synonyms:2-amino-1-phenylbutan-1-ol hydrochloride;6170-27-0;Nor-homoephedrine;Phenylbutanolamine hydrochloride;WLN: ZY2&YQR &GH;SCHEMBL5174621;NSC24527;NSC-24527;2-amino-1-phenylbutan-1-olhydrochloride;EN300-67506;Z1695783907;.alpha.-(.alpha.-Aminopropyl)benzyl alcohol hydrochloride

Chemical Property of 2-Amino-1-phenylbutan-1-ol hydrochloride

Chemical Property:

• Vapor Pressure: 0.000438mmHg at 25°C
• Boiling Point: 302.4°C at 760 mmHg
• Flash Point: 136.7°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 121

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(C1=CC=CC=C1)O)N.Cl

Technology Process of 2-Amino-1-phenylbutan-1-ol hydrochloride

There total 4 articles about 2-Amino-1-phenylbutan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-Hydroxyimino-1-phenyl-1-butanone (25994-02-9) → (+/-)-(1R,2S)-2-amino-1-phenyl-1-butanol hydrochloride (6170-27-0,101708-89-8,128161-98-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Heating;

Reference yield:

C26H33NOSi → (1RS:2RS)-2-amino-1-phenyl-butanol-(1); hydrochloride (6170-27-0,101708-89-8,128161-98-8)

Guidance literature:

C₂₆H₃₃NOSi; With hydrogen fluoride; In water; acetonitrile; at 80 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; acetonitrile; diastereoselective reaction; Inert atmosphere;

DOI:10.1080/00397911.2013.862835

Reference yield:

2-(tert-butyldiphenylsilyloxy)-2-phenylacetonitrile (910471-77-1) → (1RS:2RS)-2-amino-1-phenyl-butanol-(1); hydrochloride (6170-27-0,101708-89-8,128161-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether / 2 h / 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: hydrogen fluoride / water; acetonitrile / 24 h / 80 °C / Inert atmosphere

2.2: Inert atmosphere

With hydrogen fluoride; In diethyl ether; water; acetonitrile;

DOI:10.1080/00397911.2013.862835

upstream raw materials:

2-Hydroxyimino-1-phenyl-1-butanone

(RS)-mandelonitrile

2-(tert-butyldiphenylsilyloxy)-2-phenylacetonitrile

Downstream raw materials:

erythro-2-benzamido-1-phenylbutan-1-ol