1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione

Base Information

Chemical Name:1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione
CAS No.:131699-67-7
Molecular Formula:C₈H₁₀N₂O₃
Molecular Weight:182.179
Hs Code.:
DSSTox Substance ID:DTXSID80927322
Wikidata:Q82901943
Mol file:131699-67-7.mol

Synonyms:(+)-(S)-1,3-dimethyl-6-oxiranyl-2,4-pyrimidinedione;1,3-dimethyl-6-oxiranyl-2,4-pyrimidinedione;1,3-DOPD

Suppliers and Price of 1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Boiling Point:289.8°Cat760mmHg
Flash Point:129°C
PSA：56.53000
Density:1.393g/cm³
LogP:-0.84470
XLogP3:-1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:182.06914219
Heavy Atom Count:13
Complexity:311

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=CC(=O)N(C1=O)C)C2CO2
Isomeric SMILES:CN1C(=CC(=O)N(C1=O)C)[C@H]2CO2

Technology Process of 1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione

There total 9 articles about 1,3-Dimethyl-6-oxiranyl-2,4-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4116-39-6
1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-6-carbonsaeuremethylester

: 131699-67-7
(+)-(S)-6-Oxiranyl-1,3-dimethyl-pyrimidin-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithiumdiisopropylamide (LDA) / 1) THF, -78 deg C, 1 h, 2) THF, -78 deg C, 5 h

2: 90 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 4 h / -78 °C

3: 75 percent / PBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

4: 1) AgBF₄, 2) aq. NaOH, tetrabutylammonium fluoride (TBAF) / 1) THF, 25 deg C, 2 h, 2) 0.5 h

With sodium hydroxide; silver tetrafluoroborate; tetrabutyl ammonium fluoride; phosphorus tribromide; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)87190-8

Reference yield:

: 131699-68-8
1,3-Dimethyl-6-[2-((R)-toluene-4-sulfinyl)-acetyl]-1H-pyrimidine-2,4-dione

: 131699-67-7
(+)-(S)-6-Oxiranyl-1,3-dimethyl-pyrimidin-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 4 h / -78 °C

2: 75 percent / PBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

3: 1) AgBF₄, 2) aq. NaOH, tetrabutylammonium fluoride (TBAF) / 1) THF, 25 deg C, 2 h, 2) 0.5 h

With sodium hydroxide; silver tetrafluoroborate; tetrabutyl ammonium fluoride; phosphorus tribromide; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)87190-8

Reference yield:

: 131699-69-9
6-[(S)-1-Hydroxy-2-((R)-toluene-4-sulfinyl)-ethyl]-1,3-dimethyl-1H-pyrimidine-2,4-dione

: 131699-67-7
(+)-(S)-6-Oxiranyl-1,3-dimethyl-pyrimidin-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / PBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: 1) AgBF₄, 2) aq. NaOH, tetrabutylammonium fluoride (TBAF) / 1) THF, 25 deg C, 2 h, 2) 0.5 h

With sodium hydroxide; silver tetrafluoroborate; tetrabutyl ammonium fluoride; phosphorus tribromide; In dichloromethane;
DOI:10.1016/S0040-4020(01)87190-8