2,4-DIHYDROXY-3-NITROQUINOLINE

Base Information

• Chemical Name: 2,4-DIHYDROXY-3-NITROQUINOLINE
• CAS No.: 15151-57-2
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.158
• Hs Code.: 2933499090
• Mol file: 15151-57-2.mol

Synonyms:2,4-Quinolinediol,3-nitro- (6CI,8CI);3-Nitro-2,4-quinolinediol;4-Hydroxy-3-nitro-2(1H)-quinolinone;

Chemical Property of 2,4-DIHYDROXY-3-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 0.000282mmHg at 25°C
• Melting Point: 225 °C (decomp)(Solv: acetic acid (64-19-7))
• Refractive Index: 1.698
• Boiling Point: 309.1 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 140.7 °C
• PSA: 98.91000
• Density: 1.61 g/cm³
• LogP: 1.66510

Purity/Quality:

99%, ^*data from raw suppliers

3-Nitro-2,4-quinolinediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIHYDROXY-3-NITROQUINOLINE

There total 10 articles about 2,4-DIHYDROXY-3-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3) → 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one (15151-57-2)

Guidance literature:

With nitric acid; 1.) RT, 10 min, 2.) 75 deg C, 12 min;

DOI:10.1021/jm00023a007

Reference yield: 98.0%

→ 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one (15151-57-2)

Guidance literature:

Reference yield: 93.0%

2,4-dihydroxyquinoline (70254-44-3) → 2,4-dihydroxy-3-nitroquinoline (15151-57-2)

Guidance literature:

With nitric acid; for 0.5h; Heating;

DOI:10.1016/j.bioorg.2020.104293

upstream raw materials:

2,4-dihydroxyquinoline

4-Hydroxy-2-quinolone

5-ethyl-4-hydroxy-3-nitropyridin-2(1H)-one

aniline

Downstream raw materials:

2,4-dichloro-3-nitroquinoline

1-[2-(1-benzyl-piperidin-4-yl)-ethyl]-4-chloro-1H-imidazo[4,5-c]quinoline

tert-butyl 4-[2-(4-phenoxy-1H-imidazo[4,5-c]quinolin-1-yl)ethyl]-1-piperidinecarboxylate

1-[2-(1-benzyl-4-piperidyl)ethyl]-4-phenoxy-1H-imidazo[4,5-c]quinoline

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