Technology Process of Thunberginol B
There total 10 articles about Thunberginol B which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1248/cpb.56.1264
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / NaH / dimethylformamide / 2 h / 20 °C
2: 85 percent / ZnCl2; Pd2(dba)3; dppf / tetrahydrofuran / 17 h / 0 - 60 °C
3: 67 percent / I2 / acetonitrile / 2 h / 20 °C
4: 98 percent / formic acid; Et3N; PPh3 / Pd(OAc)2 / dimethylformamide / 60 - 63 °C
5: 81 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; formic acid; tris(dibenzylideneacetone)dipalladium (0); iodine; boron tribromide; sodium hydride; triethylamine; triphenylphosphine; zinc(II) chloride;
palladium diacetate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(03)00212-6
