151698-55-4

Basic information

• Product Name: 3-(3,4-dimethoxyphenyl)-6,8-dimethoxy-1H-isochromen-1-one
• CAS NO: 151698-55-4
• Molecular Formula: C₁₉H₁₈O₆
• Molecular Weight: 342.3426
• Mol File: 151698-55-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 532.9°C at 760 mmHg
• Flash Point: 235.7°C
• Density: 1.243g/cm³
• Vapor Pressure: 1.95E-11mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 3-(3,4-dimethoxyphenyl)-6,8-dimethoxy-1H-isochromen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxyphenyl)-6,8-dimethoxy-1H-isochromen-1-one(151698-55-4)
• EPA Substance Registry System: 3-(3,4-dimethoxyphenyl)-6,8-dimethoxy-1H-isochromen-1-one(151698-55-4)

Safety Data

• Hazardous Substances Data: 151698-55-4(Hazardous Substances Data)

Upstream product

• 6967-45-9 3,4-dimethoxy-N,N-dimethylbenzamide 
• 550365-26-9 methyl 4,6-dimethoxy-2-(perfluoro-1-butanesulfonyloxy)benzoate 
• 550365-27-0 methyl 4,6-dimethoxy-2-[(3,4-dimethoxyphenyl)ethynyl]benzoate 
• 29723-28-2 methyl 2,4,6-trimethoxybenzoate 
• 51116-92-8 methyl 4,6-dimethoxysalicylate 
• 550365-22-5 4-iodo-6,8-dimethoxy-3-(3,4-dimethoxyphenyl)isocoumarin 
• 151698-50-9 N,N-diethyl-2,4-dimethoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]-benzamide 

Downstream Products

• 147666-81-7 Thunberginol B 

Relevant articles and documents

Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen

Eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of δ- and γ-ketoamides, respectively. Subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols A, B, and F., respectively, which originated from the processed leaves of Hydrangea macrophylla Seringe var. thunbergii MAKINO. The synthesized isocoumarins and thunberginols were evaluated for their anti-allergic activity, in which thunberginol B exhibited the highest inhibitory potency on the degranulation of RBL-2H3 cells induced by antigen. Structure - activity relationship studies were carried out to determine the necessary substituents on the 3-phenylisocoumarin skeleton for inhibitory activity.

Synthesis of 3-substituted isocoumarins and related natural products

Several N,N-diethyl-2-acylmethylbenzamides (6) were prepared from N,N- diethyl-2-toluamides (4), and the ketoamides (6) were easily cyclized to the corresponding 3-substituted isocoumarins (8) by heating in acetic acid or xylene. This simple procedure was