1-Methyl-4-methylenepiperidine

Base Information

• Chemical Name: 1-Methyl-4-methylenepiperidine
• CAS No.: 13669-28-8
• Molecular Formula: C7H13N
• Molecular Weight: 111.187
• Hs Code.: 2933399090
• European Community (EC) Number: 839-554-0
• DSSTox Substance ID: DTXSID20159887
• Nikkaji Number: J636.126I
• Wikidata: Q83028267
• Mol file: 13669-28-8.mol

Synonyms:1-Methyl-4-methylenepiperidine;13669-28-8;1-methyl-4-methylidenepiperidine;1-Methyl-4-methylene-piperidine;Piperidine, 1-methyl,4-methylene-;SCHEMBL272823;SCHEMBL13240677;DTXSID20159887;4,4-methylene-1-methylpiperidine;XOLRMKKIFJFIOV-UHFFFAOYSA-N;AKOS006239061;SB41532;FT-0689896;EN300-70381

Chemical Property of 1-Methyl-4-methylenepiperidine

Chemical Property:

• Vapor Pressure: 6.13mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 140.5 °C at 760 mmHg
• Flash Point: 30.8 °C
• PSA: 3.24000
• Density: 0.87g/cm³
• LogP: 1.20610
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 111.104799419
• Heavy Atom Count: 8
• Complexity: 86.6

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-4-methylidenepiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(=C)CC1

Technology Process of 1-Methyl-4-methylenepiperidine

There total 11 articles about 1-Methyl-4-methylenepiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Methyl-4-piperidone (1445-73-4) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-methyl-4-methylene-1-azacyclohexane (13669-28-8)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;

1-Methyl-4-piperidone; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c2ob26395e

Reference yield: 51.0%

1-Methyl-4-piperidone (1445-73-4) + methyl-triphenylphosphonium iodide (2065-66-9) → 1-methyl-4-methylene-1-azacyclohexane (13669-28-8)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; for 2h; Ambient temperature;

DOI:10.1021/jo9813538

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → 1-methyl-4-methylene-1-azacyclohexane (13669-28-8)

Guidance literature:

DOI:10.1016/0040-4020(80)80171-2

upstream raw materials:

1-methyl-1-azonia-norbornane; iodide

1-Methyl-4-piperidone

methyl-triphenylphosphonium iodide

water

Downstream raw materials:

3,4-bis(3-nitrophenyl)furoxan

3,4-diphenyl-furazan 2-oxide

3-phenyl-8-methyl-1-oxa-2,8-diazaspiro<4,5>dec-2-ene

3,4-bis-(4-chloro-phenyl)-furazan 2-oxide