3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester
CAS No.:110646-22-5
Molecular Formula:C₂₂H₂₇F₃N₂O₄S
Molecular Weight:472.529
Hs Code.:
Mol file:110646-22-5.mol

Synonyms:

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester

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Technology Process of 3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 2-[[(2-aminoethyl)thio]methyl]-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl) phenyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 126199-96-0
1,1'-(dithiodi-2,1-ethanediyl)-bis(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane)

: C₂₀H₂₀F₃LiNO₄^(1-)*Li⁽¹⁺⁾

: 110646-22-5
diethyl 2-<<(2-aminoethyl)thio>methyl>-1,4-dihydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: In tetrahydrofuran; -78 degC upto room temperature;
DOI:10.1016/S0040-4039(00)99253-0

Reference yield:

: 23191-75-5
SKF 24260

: 110646-22-5
diethyl 2-<<(2-aminoethyl)thio>methyl>-1,4-dihydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C

2: 70 percent / tetrahydrofuran / -78 degC upto room temperature

With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)99253-0

Reference yield:

: 126199-96-0
1,1'-(dithiodi-2,1-ethanediyl)-bis(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane)

: 23191-75-5
SKF 24260

: 110646-22-5
diethyl 2-<<(2-aminoethyl)thio>methyl>-1,4-dihydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, n-hexane, -78 deg C, 0.5 h, 2.) -78 deg C -> room temperature;
DOI:10.1021/jo00067a012